Type II Activin Receptor (ActRIIB/ACVR2B) phosphorylates Type I Activin Receptor (ActRIC/ACVR1C) in response to NODAL

Stable Identifier
R-HSA-1225894
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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As inferred from the response of the activin receptor to activin, the type II component of the NODAL receptor phosphorylates the type I component in response to NODAL binding. As inferred from mouse and frog (Xenopus) NODAL can signal via the ACVR1C (ALK7) type I activin receptor (Reissman et al. 2001) though this may be dispensable for development in mouse (Jornvall et al. 2004).

Literature References
PubMed ID Title Journal Year
21383881 Nodal and activin receptor-like kinase 7 induce apoptosis in human breast cancer cell lines: Role of caspase 3

Zhong, Y, Xu, G, Ye, G, Lee, D, Modica-Amore, J, Peng, C

Int J Physiol Pathophysiol Pharmacol 2009
21356369 Nodal Signals through Activin Receptor-Like Kinase 7 to Inhibit Trophoblast Migration and Invasion Implication in the Pathogenesis of Preeclampsia

Nadeem, L, Munir, S, Fu, G, Dunk, C, Baczyk, D, Caniggia, I, Lye, S, Peng, C

Am J Pathol 2011
11485994 The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development

Reissmann, E, Jörnvall, H, Blokzijl, A, Andersson, O, Chang, C, Minchiotti, G, Persico, MG, Ibáñez, CF, Brivanlou, AH

Genes Dev 2001
15485907 ALK7, a receptor for nodal, is dispensable for embryogenesis and left-right patterning in the mouse

Jörnvall, H, Reissmann, E, Andersson, O, Mehrkash, M, Ibáñez, CF

Mol Cell Biol 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of NODAL:ACVR1C:ACVR2B:EGF-CFC [plasma membrane]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created