Reactome | Signaling by NODAL

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Signaling by NODAL Show undefined attributes

authored	[InstanceEdit:1181143] May, B, 2011-01-23
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:7660] nucleoplasm [Compartment:876] plasma membrane
created	[InstanceEdit:1181146] May, B, 2011-01-27
crossReference	[DatabaseIdentifier:12819621] BioModels Database:BIOMD0000000173
dbId	1181150
displayName	Signaling by NODAL
doi	10.3180/REACT_111057.1
edited	[InstanceEdit:1181143] May, B, 2011-01-23
eventOf	[TopLevelPathway:R-HSA-1266738] Developmental Biology - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-1181152] Cleavage of NODAL proprotein - Homo sapiens [Reaction:R-HSA-1181155] The NODAL Receptor binds NODAL ligands - Homo sapiens [Reaction:R-HSA-1181156] Type II Activin Receptor (ActRII/ACVR2) phosphorylates Type I Activin Receptor (ActRIB/ACVR1B) in response to NODAL - Homo sapiens [Reaction:R-HSA-1225894] Type II Activin Receptor (ActRIIB/ACVR2B) phosphorylates Type I Activin Receptor (ActRIC/ACVR1C) in response to NODAL - Homo sapiens [Reaction:R-HSA-1181355] Phosphorylation of R-SMAD2/3 by NODAL receptor - Homo sapiens [Reaction:R-HSA-170847] Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 - Homo sapiens [BlackBoxEvent:R-HSA-173488] The SMAD2/3:SMAD4 complex transfers to the nucleus - Homo sapiens [Reaction:R-HSA-1225919] Phospho R-SMAD(SMAD2,3):CO-SMAD(SMAD4):FOXH1 binds Activin Response Element - Homo sapiens [Reaction:R-HSA-1535903] Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements - Homo sapiens [Pathway:R-HSA-1433617] Regulation of signaling by NODAL - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2021-09-15
literatureReference	[LiteratureReference:1226000] Nodal morphogens [LiteratureReference:1225990] Nodal signaling: developmental roles and regulation
maxDepth	3
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	Signaling by NODAL
orthologousEvent	[Pathway:R-CEL-1181150] Signaling by NODAL - Caenorhabditis elegans [Pathway:R-DME-1181150] Signaling by NODAL - Drosophila melanogaster [Pathway:R-GGA-1181150] Signaling by NODAL - Gallus gallus [Pathway:R-XTR-1181150] Signaling by NODAL - Xenopus tropicalis [Pathway:R-SSC-1181150] Signaling by NODAL - Sus scrofa [Pathway:R-BTA-1181150] Signaling by NODAL - Bos taurus [Pathway:R-CFA-1181150] Signaling by NODAL - Canis familiaris [Pathway:R-RNO-1181150] Signaling by NODAL - Rattus norvegicus [Pathway:R-MMU-1181150] Signaling by NODAL - Mus musculus
releaseDate	2011-09-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1529118] Peng, C, 2011-08-24
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-1181150
summation	[Summation:1226001] Signaling by NODAL is essential for patterning of the axes o...
updateTrackers	[UpdateTracker:9788177] Update Tracker - [Pathway:1181150] Signaling by NODAL - v43:[updateContainedRLE] [UpdateTracker:9788641] Update Tracker - [Pathway:1181150] Signaling by NODAL - v41:[updateContainedRLE] [UpdateTracker:9784164] Update Tracker - [Pathway:1181150] Signaling by NODAL - v54:[updateContainedRLE, updateIndirectRLE] [UpdateTracker:9782762] Update Tracker - [Pathway:1181150] Signaling by NODAL - v58:[updateContainedRLE, updateIndirectRLE] [UpdateTracker:9786217] Update Tracker - [Pathway:1181150] Signaling by NODAL - v50:[updateContainedRLE] [UpdateTracker:9787894] Update Tracker - [Pathway:1181150] Signaling by NODAL - v44:[updateContainedRLE] [UpdateTracker:9779521] Update Tracker - [Pathway:1181150] Signaling by NODAL - v65:[updateContainedRLE] [UpdateTracker:9775721] Update Tracker - [Pathway:1181150] Signaling by NODAL - v78:[updateContainedRLE]

Referrals

(updatedInstance)

[UpdateTracker:9788177] Update Tracker - [Pathway:1181150] Signaling by NODAL - v43:[updateContainedRLE]
[UpdateTracker:9788641] Update Tracker - [Pathway:1181150] Signaling by NODAL - v41:[updateContainedRLE]
[UpdateTracker:9784164] Update Tracker - [Pathway:1181150] Signaling by NODAL - v54:[updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9782762] Update Tracker - [Pathway:1181150] Signaling by NODAL - v58:[updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9786217] Update Tracker - [Pathway:1181150] Signaling by NODAL - v50:[updateContainedRLE]
[UpdateTracker:9787894] Update Tracker - [Pathway:1181150] Signaling by NODAL - v44:[updateContainedRLE]
[UpdateTracker:9779521] Update Tracker - [Pathway:1181150] Signaling by NODAL - v65:[updateContainedRLE]
[UpdateTracker:9775721] Update Tracker - [Pathway:1181150] Signaling by NODAL - v78:[updateContainedRLE]

(hasEvent)

[TopLevelPathway:R-HSA-1266738] Developmental Biology

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