Reactome | EGFR L858R;T790M [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:1181385] Orlic-Milacic, Marija, 2011-02-07
dbId	1181386
disease	[Disease:1247848] non-small cell lung carcinoma [Disease:1500689] cancer [Disease:1500699] lung cancer
displayName	EGFR L858R;T790M [plasma membrane]
endCoordinate	1210
hasModifiedResidue	[ReplacedResidue:1173209] L-leucine 858 replaced with L-arginine [ReplacedResidue:1181394] L-threonine 790 replaced with L-methionine
inDisease	true
literatureReference	[LiteratureReference:1169414] Structures of lung cancer-derived EGFR mutants and inhibitor complexes: mechanism of activation and insights into differential inhibitor sensitivity [LiteratureReference:1181387] Novel D761Y and common secondary T790M mutations in epidermal growth factor receptor-mutant lung adenocarcinomas with acquired resistance to kinase inhibitors
memberOf	[CandidateSet:R-HSA-1182967] Ligand-responsive EGFR mutants resistant to non-covalent TKIs [plasma membrane] - Homo sapiens
modified	[InstanceEdit:3662293] Orlic-Milacic, M, 2013-06-06
name	EGFR L858R;T790M Epidermal Growth Factor Receptor L858R T790M EGFR Leu858Arg;Thr790Met
referenceEntity	[ReferenceGeneProduct:54208] UniProt:P00533 EGFR
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-1181386
startCoordinate	25
summation	[Summation:1181388] Secondary mutation T790M in EGFR L858R mutant confers TKI re...

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