Reactome | Secondary mutation T790M in EGFR L858R mutant confers TKI re...

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created	[InstanceEdit:1181385] Orlic-Milacic, Marija, 2011-02-07
dbId	1181388
displayName	Secondary mutation T790M in EGFR L858R mutant confers TKI re...
literatureReference	[LiteratureReference:1181387] Novel D761Y and common secondary T790M mutations in epidermal growth factor receptor-mutant lung adenocarcinomas with acquired resistance to kinase inhibitors
schemaClass	Summation
text	Secondary mutation T790M in EGFR L858R mutant confers TKI resistance and results in cancer progression in patients initially responsive to TKI therapy (Balak et al. 2006).

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