Reactome | EGFR E746_A750del [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

EGFR E746_A750del [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:1181209] Orlic-Milacic, Marija, 2011-01-31
crossReference	[DatabaseIdentifier:1655478] COSMIC:COSV51765119 [DatabaseIdentifier:1655482] COSMIC:COSM12980 [DatabaseIdentifier:1655485] COSMIC:COSV51765066
dbId	1181211
disease	[Disease:1500689] cancer [Disease:1500699] lung cancer [Disease:1247848] non-small cell lung carcinoma [Disease:1655480] salivary gland cancer [Disease:1655479] parotid gland cancer [Disease:1655470] thyroid cancer [Disease:1655467] papillary thyroid carcinoma [Disease:1500575] ovarian cancer [Disease:1248679] head and neck squamous cell carcinoma [Disease:1655483] renal clear cell carcinoma [Disease:1655484] kidney cancer [Disease:1500576] breast cancer
displayName	EGFR E746_A750del [plasma membrane]
endCoordinate	1210
hasModifiedResidue	[FragmentDeletionModification:9626687] Deletion of residues 746 to 750
inDisease	true
literatureReference	[LiteratureReference:1181035] Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
memberOf	[CandidateSet:R-HSA-1176052] Ligand-responsive EGFR mutants sensitive to non-covalent TKIs [plasma membrane] - Homo sapiens
modified	[InstanceEdit:9626688] Orlic-Milacic, Marija, 2018-10-29
name	EGFR E746_A750del Epidermal Growth Factor Receptor E746_A750del EGFR Glu746_Ala750del
referenceEntity	[ReferenceGeneProduct:54208] UniProt:P00533 EGFR
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-1181211
startCoordinate	25

Referrals

(hasMember)

[CandidateSet:R-HSA-1176052] Ligand-responsive EGFR mutants sensitive to non-covalent TKIs [plasma membrane]

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