Reactome | EGFR L861Q [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

EGFR L861Q [plasma membrane] Show undefined attributes

candidateOf	[CandidateSet:R-HSA-1176052] Ligand-responsive EGFR mutants sensitive to non-covalent TKIs [plasma membrane] - Homo sapiens
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:1177539] Orlic-Milacic, Marija, 2011-01-25
crossReference	[DatabaseIdentifier:12020794] Mondo:0005233 [DatabaseIdentifier:1655474] COSMIC:COSV51766344 [DatabaseIdentifier:1655476] COSMIC:COSM13173
dbId	1177542
disease	[Disease:1247848] non-small cell lung carcinoma [Disease:1500699] lung cancer [Disease:1500689] cancer [Disease:1247632] glioblastoma [Disease:1996318] astrocytoma [Disease:1996312] brain glioma
displayName	EGFR L861Q [plasma membrane]
endCoordinate	1210
hasModifiedResidue	[ReplacedResidue:1177540] L-leucine 861 replaced with L-glutamine
inDisease	true
literatureReference	[LiteratureReference:1181011] An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor [LiteratureReference:1181035] Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
maxDepth	1
modified	[InstanceEdit:3662293] Orlic-Milacic, M, 2013-06-06
name	EGFR L861Q Epidermal Growth Factor Receptor L861Q EGFR Leu861Gln
referenceEntity	[ReferenceGeneProduct:uniprot:P00533] UniProt:P00533 EGFR
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-1177542
startCoordinate	25
summation	[Summation:1181055] L861Q, a substitution of leucine 861 with glutamine, is a do...
updateTrackers	[UpdateTracker:9887707] Update Tracker - [EntityWithAccessionedSequence:1177542] EGFR L861Q [plasma membrane] - v46:[modifyName]

Referrals

(updatedInstance)	[UpdateTracker:9887707] Update Tracker - [EntityWithAccessionedSequence:1177542] EGFR L861Q [plasma membrane] - v46:[modifyName]
(hasCandidate)	[CandidateSet:R-HSA-1176052] Ligand-responsive EGFR mutants sensitive to non-covalent TKIs [plasma membrane]

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