Reactome | EGFR G719A [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

candidateOf	[CandidateSet:R-HSA-1176052] Ligand-responsive EGFR mutants sensitive to non-covalent TKIs [plasma membrane] - Homo sapiens
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:1177529] Orlic-Milacic, Marija, 2011-01-25
crossReference	[DatabaseIdentifier:12020794] Mondo:0005233 [DatabaseIdentifier:1655450] COSMIC:COSV51769339 [DatabaseIdentifier:1655449] COSMIC:COSM13448
dbId	1177532
disease	[Disease:1247848] non-small cell lung carcinoma [Disease:1500699] lung cancer [Disease:1500689] cancer
displayName	EGFR G719A [plasma membrane]
endCoordinate	1210
hasModifiedResidue	[ReplacedResidue:1177533] glycine 719 replaced with L-alanine
inDisease	true
literatureReference	[LiteratureReference:1169414] Structures of lung cancer-derived EGFR mutants and inhibitor complexes: mechanism of activation and insights into differential inhibitor sensitivity
maxDepth	1
modified	[InstanceEdit:3662293] Orlic-Milacic, M, 2013-06-06
name	EGFR G719A Epidermal Growth Factor Receptor G719A EGFR Gly719Ala
referenceEntity	[ReferenceGeneProduct:uniprot:P00533] UniProt:P00533 EGFR
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-1177532
startCoordinate	25
updateTrackers	[UpdateTracker:9888084] Update Tracker - [EntityWithAccessionedSequence:1177532] EGFR G719A [plasma membrane] - v46:[modifyName]

(updatedInstance)	[UpdateTracker:9888084] Update Tracker - [EntityWithAccessionedSequence:1177532] EGFR G719A [plasma membrane] - v46:[modifyName]
(hasCandidate)	[CandidateSet:R-HSA-1176052] Ligand-responsive EGFR mutants sensitive to non-covalent TKIs [plasma membrane]

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