Reactome | EGFR L858R [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

EGFR L858R [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:1173208] Orlic-Milacic, Marija, 2011-01-21
crossReference	[DatabaseIdentifier:12021382] Mondo:0006456 [DatabaseIdentifier:1655469] COSMIC:COSV51765161 [DatabaseIdentifier:1655471] COSMIC:COSM12979
dbId	1173212
disease	[Disease:1500689] cancer [Disease:1500699] lung cancer [Disease:1247848] non-small cell lung carcinoma [Disease:1655468] thymus cancer [Disease:1655472] thymoma [Disease:1655470] thyroid cancer [Disease:1655467] papillary thyroid carcinoma [Disease:1500687] stomach cancer [Disease:1500576] breast cancer [Disease:1500575] ovarian cancer [Disease:1655473] malignant peritoneal mesothelioma
displayName	EGFR L858R [plasma membrane]
endCoordinate	1210
hasModifiedResidue	[ReplacedResidue:1173209] L-leucine 858 replaced with L-arginine
inDisease	true
literatureReference	[LiteratureReference:1169414] Structures of lung cancer-derived EGFR mutants and inhibitor complexes: mechanism of activation and insights into differential inhibitor sensitivity [LiteratureReference:1181048] EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib
maxDepth	1
memberOf	[CandidateSet:R-HSA-1176052] Ligand-responsive EGFR mutants sensitive to non-covalent TKIs [plasma membrane] - Homo sapiens
modified	[InstanceEdit:3662293] Orlic-Milacic, M, 2013-06-06
name	EGFR L858R Epidermal Growth Factor Receptor L858R EGFR Leu858Arg
referenceEntity	[ReferenceGeneProduct:uniprot:P00533] UniProt:P00533 EGFR
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-1173212
startCoordinate	25
summation	[Summation:1181056] L858R, a substitution of leucine 858 with arginine, accounts...
updateTrackers	[UpdateTracker:9888372] Update Tracker - [EntityWithAccessionedSequence:1173212] EGFR L858R [plasma membrane] - v46:[modifyName]

Referrals

(updatedInstance)	[UpdateTracker:9888372] Update Tracker - [EntityWithAccessionedSequence:1173212] EGFR L858R [plasma membrane] - v46:[modifyName]
(hasMember)	[CandidateSet:R-HSA-1176052] Ligand-responsive EGFR mutants sensitive to non-covalent TKIs [plasma membrane]

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