Reactome | EGFR G719S [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:1169427] Orlic-Milacic, Marija, 2011-01-18
crossReference	[DatabaseIdentifier:12020752] Mondo:0005575 [DatabaseIdentifier:1655464] COSMIC:COSV51767289 [DatabaseIdentifier:1655461] COSMIC:COSM13983
dbId	1169418
disease	[Disease:1247848] non-small cell lung carcinoma [Disease:1500699] lung cancer [Disease:1500689] cancer [Disease:1248674] large intestine cancer
displayName	EGFR G719S [plasma membrane]
endCoordinate	1210
hasModifiedResidue	[ReplacedResidue:1169422] glycine 719 replaced with L-serine
inDisease	true
literatureReference	[LiteratureReference:1169414] Structures of lung cancer-derived EGFR mutants and inhibitor complexes: mechanism of activation and insights into differential inhibitor sensitivity
maxDepth	1
memberOf	[CandidateSet:R-HSA-1176052] Ligand-responsive EGFR mutants sensitive to non-covalent TKIs [plasma membrane] - Homo sapiens
modified	[InstanceEdit:3662293] Orlic-Milacic, M, 2013-06-06
name	EGFR G719S Epidermal Growth Factor Receptor G719S EGFR Gly719Ser
referenceEntity	[ReferenceGeneProduct:uniprot:P00533] UniProt:P00533 EGFR
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-1169418
startCoordinate	25
updateTrackers	[UpdateTracker:9888410] Update Tracker - [EntityWithAccessionedSequence:1169418] EGFR G719S [plasma membrane] - v46:[modifyName]

(updatedInstance)	[UpdateTracker:9888410] Update Tracker - [EntityWithAccessionedSequence:1169418] EGFR G719S [plasma membrane] - v46:[modifyName]
(hasMember)	[CandidateSet:R-HSA-1176052] Ligand-responsive EGFR mutants sensitive to non-covalent TKIs [plasma membrane]

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