Reactome | PRKCB (PKC-beta) phosphorylates CARMA1

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PRKCB (PKC-beta) phosphorylates CARMA1 Show undefined attributes

authored	[InstanceEdit:1168382] May, B, 2010-12-18
catalystActivity	[CatalystActivity:1168628] protein serine/threonine kinase activity of Activated PKC beta [plasma membrane]
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:1168634] May, B, 2011-01-03
dbId	1168635
displayName	PRKCB (PKC-beta) phosphorylates CARMA1
edited	[InstanceEdit:1168382] May, B, 2010-12-18
eventOf	[Pathway:R-HSA-1169091] Activation of NF-kappaB in B cells - Homo sapiens
followingEvent	[Reaction:R-HSA-1168644] CARMA1 recruits MALT1 and BCL10 forming CBM Complex - Homo sapiens
input	6 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-1169088] CARMA1 oligomer [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1169052] Phosphorylation of the CARMA1 linker controls NF-kappaB activation
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	PRKCB (PKC-beta) phosphorylates CARMA1
orthologousEvent	[BlackBoxEvent:R-GGA-1168635] PRKCB (PKC-beta) phosphorylates CARMA1 - Gallus gallus [BlackBoxEvent:R-XTR-1168635] PRKCB (PKC-beta) phosphorylates CARMA1 - Xenopus tropicalis [BlackBoxEvent:R-BTA-1168635] PRKCB (PKC-beta) phosphorylates CARMA1 - Bos taurus [BlackBoxEvent:R-CFA-1168635] PRKCB (PKC-beta) phosphorylates CARMA1 - Canis familiaris [BlackBoxEvent:R-RNO-1168635] PRKCB (PKC-beta) phosphorylates CARMA1 - Rattus norvegicus [BlackBoxEvent:R-MMU-1168635] PRKCB (PKC-beta) phosphorylates CARMA1 - Mus musculus
output	6 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-1168616] p-CARMA1 Oligomer [plasma membrane]
precedingEvent	[Reaction:R-HSA-1168373] PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine - Homo sapiens
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2108988] Wienands, J, 2012-02-11
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-1168635
summation	[Summation:1168632] CARMA1 is phosphorylated at serines 559, 644, and 652 by Pro...

Referrals

(hasEvent)	[Pathway:R-HSA-1169091] Activation of NF-kappaB in B cells
(precedingEvent)	[Reaction:R-HSA-1168644] CARMA1 recruits MALT1 and BCL10 forming CBM Complex

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