Reactome | PRKCB (PKC-beta) phosphorylates CARMA1

PRKCB (PKC-beta) phosphorylates CARMA1

Stable Identifier

R-HSA-1168635

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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CARMA1 is phosphorylated at serines 559, 644, and 652 by Protein Kinase C beta (PKC-beta) (Sommer et al. 2005). CARMA1 is constitutively oligomerized (Tanner et al. 2007) and most CARMA1 in unstimulated cells is cytosolic (Sommer et al. 2005, Tanner et al. 2007), though a portion is constitutively associated with the plasma membrane (Gaide et al. 2002, Sommer et al. 2005). After phosphorylation, CARMA1 is associated with lipid rafts in the plasma membrane (Sommer et al. 2005). Note that some publications refer to CARMA1 with a different N-terminal methionine that is 7 amino acids shorter. In this case the phosphorylated serines are 552, 537, and 645.

Literature References

PubMed ID	Title	Journal	Year
16356855	Phosphorylation of the CARMA1 linker controls NF-kappaB activation Sommer, K, Guo, B, Pomerantz, JL, Bandaranayake, AD, Moreno-Garcia, ME, Ovechkina, YL, Rawlings, DJ	Immunity	2005