PRKCB (PKC-beta) phosphorylates CARMA1

Stable Identifier
Reaction [BlackBoxEvent]
Homo sapiens
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CARMA1 is phosphorylated at serines 559, 644, and 652 by Protein Kinase C beta (PKC-beta) (Sommer et al. 2005). CARMA1 is constitutively oligomerized (Tanner et al. 2007) and most CARMA1 in unstimulated cells is cytosolic (Sommer et al. 2005, Tanner et al. 2007), though a portion is constitutively associated with the plasma membrane (Gaide et al. 2002, Sommer et al. 2005). After phosphorylation, CARMA1 is associated with lipid rafts in the plasma membrane (Sommer et al. 2005). Note that some publications refer to CARMA1 with a different N-terminal methionine that is 7 amino acids shorter. In this case the phosphorylated serines are 552, 537, and 645.

Literature References
PubMed ID Title Journal Year
16356855 Phosphorylation of the CARMA1 linker controls NF-kappaB activation

Sommer, K, Pomerantz, JL, Rawlings, DJ, Guo, B, Bandaranayake, AD, Ovechkina, YL, Moreno-Garcia, ME

Immunity 2005
Catalyst Activity

protein serine/threonine kinase activity of Activated PKC beta [plasma membrane]

Orthologous Events
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