RasGRP1 and RasGRP3 binds diacylglycerol and is phosphorylated

Stable Identifier
R-HSA-1168374
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
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RasGRP1 and RasGRP3 binds diacylglycerol and is phosphorylated
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RasGRP1 and RasGRP3 translocate to the plasma membrane where they bind diacylglycerol (Lorenzo et al. 2001) and are phosphorylated (Teixeira et al. 2003, Zheng et al. 2005). Though RasGRP3 is phosphorylated in vitro and in some cell lines (e.g. Ramos cells) by protein kinase C theta (PKC-theta, Zheng et al. 2005), normal B cells do not contain PKC-theta (Meller et al. 1999). Both Rasgrp1 and Rasgrp3 participate in activating Ras in response to BCR signaling in mouse B cells (Coughlin et al. 2005).

Literature References
PubMed ID Title Journal Year
10222061 Protein kinase C-theta (PKCtheta) distribution analysis in hematopoietic cells: proliferating T cells exhibit high proportions of PKCtheta in the particulate fraction

Meller, N, Elitzur, Y, Isakov, N

Cell Immunol 1999
16301621 RasGRP1 and RasGRP3 regulate B cell proliferation by facilitating B cell receptor-Ras signaling

Coughlin, JJ, Stang, SL, Dower, NA, Stone, JC

J Immunol 2005
12730099 Integration of DAG signaling systems mediated by PKC-dependent phosphorylation of RasGRP3

Teixeira, C, Stang, SL, Zheng, Y, Beswick, NS, Stone, JC

Blood 2003
15657177 Phosphorylation of RasGRP3 on threonine 133 provides a mechanistic link between PKC and Ras signaling systems in B cells

Zheng, Y, Liu, H, Coughlin, J, Zheng, J, Li, L, Stone, JC

Blood 2005
11221888 Phorbol esters modulate the Ras exchange factor RasGRP3

Lorenzo, PS, Kung, JW, Bottorff, DA, Garfield, SH, Stone, JC, Blumberg, PM

Cancer Res 2001
Participants
Input
Output
Participant Of
hasEvent
Inferred From
Rasgrp1 and Rasgrp3 are recruited to the membrane and phosphorylated (Mus musculus)
Authored
May, B  (2011-01-04)
Reviewed
Wienands, J  (2012-02-12)
Created
May, B  (2010-12-19)