Reactome | Thrombin-activated PARs activate Gq

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Thrombin-activated PARs activate Gq Show undefined attributes

catalystActivity	[CatalystActivity:139932] G protein-coupled receptor activity of Thrombin-activated PARs [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:141659] de Bono, B, Pace, N.P., Farndale, R, 2004-09-25 17:06:19
dbId	114558
displayName	Thrombin-activated PARs activate Gq
eventOf	[Pathway:R-HSA-456926] Thrombin signalling through proteinase activated receptors (PARs) - Homo sapiens
followingEvent	[Reaction:R-HSA-397835] Thrombin-activated PARs:Gq (active) dissociate - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-HSA-397803] Thrombin-activated PARs:Gq (inactive) [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:397801] Protease-activated receptors in hemostasis, thrombosis and vascular biology
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Thrombin-activated PARs activate Gq Gq activation by PAR
orthologousEvent	[Reaction:R-CEL-114558] Thrombin-activated PARs activate Gq - Caenorhabditis elegans [Reaction:R-GGA-114558] Thrombin-activated PARs activate Gq - Gallus gallus [Reaction:R-XTR-114558] Thrombin-activated PARs activate Gq - Xenopus tropicalis [Reaction:R-DRE-114558] Thrombin-activated PARs activate Gq - Danio rerio [Reaction:R-SSC-114558] Thrombin-activated PARs activate Gq - Sus scrofa [Reaction:R-BTA-114558] Thrombin-activated PARs activate Gq - Bos taurus [Reaction:R-CFA-114558] Thrombin-activated PARs activate Gq - Canis familiaris [Reaction:R-RNO-114558] Thrombin-activated PARs activate Gq - Rattus norvegicus [Reaction:R-MMU-114558] Thrombin-activated PARs activate Gq - Mus musculus
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-HSA-397802] Thrombin-activated PAR:Gq (active) [plasma membrane]
precedingEvent	[Reaction:R-HSA-396996] Thrombin-activated PARs binds G-protein Gq - Homo sapiens
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-114558
summation	[Summation:178829] Activated PAR stimulates the G alpha (q) subunit to release ...
updateTrackers	[UpdateTracker:9791596] Update Tracker - [Reaction:114558] Thrombin-activated PARs activate Gq - v28:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText] [UpdateTracker:9791470] Update Tracker - [Reaction:114558] Thrombin-activated PARs activate Gq - v30:[removeLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9791596] Update Tracker - [Reaction:114558] Thrombin-activated PARs activate Gq - v28:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText] [UpdateTracker:9791470] Update Tracker - [Reaction:114558] Thrombin-activated PARs activate Gq - v30:[removeLiteratureReference]
(hasEvent)	[Pathway:R-HSA-456926] Thrombin signalling through proteinase activated receptors (PARs)
(precedingEvent)	[Reaction:R-HSA-397835] Thrombin-activated PARs:Gq (active) dissociate