Gq activation by PAR

Stable Identifier
R-HSA-114558
Type
Reaction
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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Gq activation by PAR
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Activated PAR stimulates the G alpha (q) subunit to release GDP and bind GTP (which is present in much greater concentrations physiologically). This activation is required for Gq to participate in downstream signalling events.

Literature References
PubMed ID Title Journal Year
16102047 Protease-activated receptors in hemostasis, thrombosis and vascular biology

Coughlin, SR

J Thromb Haemost 2005
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
G protein-coupled receptor activity of Thrombin-activated PAR [plasma membrane]
Physical Entity
Thrombin-activated PAR [plasma membrane]
Activity
G protein-coupled receptor activity (0004930)
Orthologous Events
Gq activation by PAR (Bos taurus)
Gq activation by PAR (Caenorhabditis elegans)
Gq activation by PAR (Canis familiaris)
Gq activation by PAR (Danio rerio)
Gq activation by PAR (Gallus gallus)
Gq activation by PAR (Mus musculus)
Gq activation by PAR (Rattus norvegicus)
Gq activation by PAR (Sus scrofa)
Gq activation by PAR (Xenopus tropicalis)
Created
de Bono, B  (2004-09-25)
Pace, NP  (2004-09-25)
Farndale, R  (2004-09-25)
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