Thrombin-activated PARs activate Gq

Stable Identifier
R-HSA-114558
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Gq activation by PAR
Locations in the PathwayBrowser
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Activated PAR stimulates the G alpha (q) subunit to release GDP and bind GTP (which is present in much greater concentrations physiologically). This activation is required for Gq to participate in downstream signalling events.

Literature References
PubMed ID Title Journal Year
16102047 Protease-activated receptors in hemostasis, thrombosis and vascular biology

Coughlin, SR

J Thromb Haemost 2005
Participants
Participates
Catalyst Activity

G protein-coupled receptor activity of Thrombin-activated PARs [plasma membrane]

Orthologous Events
Created
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