Thrombin-activated PARs activate Gq

Stable Identifier
R-HSA-114558
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
Synonyms
Gq activation by PAR
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Thrombin-activated PARs activate Gq
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Activated PAR stimulates the G alpha (q) subunit to release GDP and bind GTP (which is present in much greater concentrations physiologically). This activation is required for Gq to participate in downstream signalling events.

Literature References
PubMed ID Title Journal Year
16102047 Protease-activated receptors in hemostasis, thrombosis and vascular biology

Coughlin, SR

J Thromb Haemost 2005
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Catalyst Activity

G protein-coupled receptor activity of Thrombin-activated PARs [plasma membrane]

Physical Entity
Thrombin-activated PARs [plasma membrane] (Homo sapiens)
Activity
G protein-coupled receptor activity (GO:0004930)
Orthologous Events
Thrombin-activated PARs activate Gq (Bos taurus)
Thrombin-activated PARs activate Gq (Caenorhabditis elegans)
Thrombin-activated PARs activate Gq (Canis familiaris)
Thrombin-activated PARs activate Gq (Danio rerio)
Thrombin-activated PARs activate Gq (Gallus gallus)
Thrombin-activated PARs activate Gq (Mus musculus)
Thrombin-activated PARs activate Gq (Rattus norvegicus)
Thrombin-activated PARs activate Gq (Sus scrofa)
Thrombin-activated PARs activate Gq (Xenopus tropicalis)
Created
Farndale, R  (2004-09-25)
Pace, NP  (2004-09-25)
de Bono, B  (2004-09-25)
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