Reactome | Oligomerization of BAK at the mitochondrial membrane

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Oligomerization of BAK at the mitochondrial membrane Show undefined attributes

category	binding
compartment	[Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:139911] Hardwick, JM, Tsujimoto, Y, 2004-08-09 19:10:09
dbId	114263
displayName	Oligomerization of BAK at the mitochondrial membrane
eventOf	[Pathway:R-HSA-111452] Activation and oligomerization of BAK protein - Homo sapiens
followingEvent	[Reaction:R-HSA-114284] Release of Cytochrome c from mitochondria - Homo sapiens [Reaction:R-HSA-114307] Release of SMAC (DIABLO) from mitochondria - Homo sapiens
input	2 × [EntityWithAccessionedSequence:R-HSA-50690] BAK1 activated [mitochondrial outer membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:139821] BCL-2 selectively interacts with the BID-induced open conformer of BAK, inhibiting BAK auto-oligomerization
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Oligomerization of BAK at the mitochondrial membrane
orthologousEvent	[Reaction:R-GGA-114263] Oligomerization of BAK at the mitochondrial membrane - Gallus gallus [Reaction:R-SSC-114263] Oligomerization of BAK at the mitochondrial membrane - Sus scrofa [Reaction:R-BTA-114263] Oligomerization of BAK at the mitochondrial membrane - Bos taurus [Reaction:R-CFA-114263] Oligomerization of BAK at the mitochondrial membrane - Canis familiaris [Reaction:R-RNO-114263] Oligomerization of BAK at the mitochondrial membrane - Rattus norvegicus [Reaction:R-MMU-114263] Oligomerization of BAK at the mitochondrial membrane - Mus musculus
output	[Complex:R-HSA-114262] Active oligomeric BAK [mitochondrial outer membrane]
precedingEvent	[Reaction:R-HSA-139895] tBID activates BAK protein - Homo sapiens
releaseDate	2004-10-27
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-114263
summation	[Summation:179007] Once activated BAK insterts in the outer mitochondrial membr...
updateTrackers	[UpdateTracker:9787640] Update Tracker - [Reaction:114263] Oligomerization of BAK at the mitochondrial membrane - v44:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9787640] Update Tracker - [Reaction:114263] Oligomerization of BAK at the mitochondrial membrane - v44:[modifyText]
(hasEvent)	[Pathway:R-HSA-111452] Activation and oligomerization of BAK protein
(precedingEvent)	[Reaction:R-HSA-114284] Release of Cytochrome c from mitochondria [Reaction:R-HSA-114307] Release of SMAC (DIABLO) from mitochondria

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