Reactome | Neurotransmitter release cycle

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Neurotransmitter release cycle Show undefined attributes

authored	[InstanceEdit:210542] Mahajan, SS, 2008-01-14 16:01:52
created	[InstanceEdit:112300] Joshi-Tope, G, 2004-04-22 09:35:00
dbId	112310
diseasePathways	[Pathway:R-HSA-5619114] Defective SLC5A7 in the neurotransmitter release cycle causes distal hereditary motor neuronopathy 7A (HMN7A) - Homo sapiens
displayName	Neurotransmitter release cycle
edited	[InstanceEdit:210542] Mahajan, SS, 2008-01-14 16:01:52
eventOf	[Pathway:R-HSA-112315] Transmission across Chemical Synapses - Homo sapiens
followingEvent	[Pathway:R-HSA-112313] Neurotransmitter uptake and metabolism In glial cells - Homo sapiens [Pathway:R-HSA-112314] Neurotransmitter receptors and postsynaptic signal transmission - Homo sapiens [Pathway:R-HSA-112311] Neurotransmitter clearance - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:20323] neurotransmitter secretion
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-HSA-181430] Norepinephrine Neurotransmitter Release Cycle - Homo sapiens [Pathway:R-HSA-181429] Serotonin Neurotransmitter Release Cycle - Homo sapiens [Pathway:R-HSA-210500] Glutamate Neurotransmitter Release Cycle - Homo sapiens [Pathway:R-HSA-212676] Dopamine Neurotransmitter Release Cycle - Homo sapiens [Pathway:R-HSA-264642] Acetylcholine Neurotransmitter Release Cycle - Homo sapiens [Pathway:R-HSA-888590] GABA synthesis, release, reuptake and degradation - Homo sapiens [Reaction:R-HSA-6803753] NAAA hydrolyses NAEs to FAs and ethanolamine - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2023-09-13
literatureReference	[LiteratureReference:349561] The neurotransmitter cycle and quantal size [LiteratureReference:379284] Vesicle pools, docking, priming, and release [LiteratureReference:379281] The synaptic vesicle cycle [LiteratureReference:379286] Molecular organization of the presynaptic active zone
maxDepth	4
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Neurotransmitter release cycle
orthologousEvent	[Pathway:R-MMU-112310] Neurotransmitter release cycle - Mus musculus [Pathway:R-RNO-112310] Neurotransmitter release cycle - Rattus norvegicus [Pathway:R-CFA-112310] Neurotransmitter release cycle - Canis familiaris [Pathway:R-BTA-112310] Neurotransmitter release cycle - Bos taurus [Pathway:R-SSC-112310] Neurotransmitter release cycle - Sus scrofa [Pathway:R-DRE-112310] Neurotransmitter release cycle - Danio rerio [Pathway:R-XTR-112310] Neurotransmitter release cycle - Xenopus tropicalis [Pathway:R-GGA-112310] Neurotransmitter release cycle - Gallus gallus [Pathway:R-DME-112310] Neurotransmitter release cycle - Drosophila melanogaster [Pathway:R-CEL-112310] Neurotransmitter release cycle - Caenorhabditis elegans [Pathway:R-DDI-112310] Neurotransmitter release cycle - Dictyostelium discoideum [Pathway:R-SPO-112310] Neurotransmitter release cycle - Schizosaccharomyces pombe [Pathway:R-PFA-112310] Neurotransmitter release cycle - Plasmodium falciparum [Pathway:R-SCE-112310] Neurotransmitter release cycle - Saccharomyces cerevisiae
precedingEvent	[Pathway:R-HSA-112313] Neurotransmitter uptake and metabolism In glial cells - Homo sapiens [Pathway:R-HSA-112308] Presynaptic depolarization and calcium channel opening - Homo sapiens
releaseDate	2008-06-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:387389] Restituito, S, Kavalali, E, 2008-12-02 04:33:19
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-112310
summation	[Summation:349545] Neurotransmitter is stored in the synaptic vesicle in the pr...
updateTrackers	[UpdateTracker:9789255] Update Tracker - [Pathway:112310] Neurotransmitter release cycle - v38:[updateContainedPathway] [UpdateTracker:9786361] Update Tracker - [Pathway:112310] Neurotransmitter release cycle - v49:[updateIndirectRLE] [UpdateTracker:9785994] Update Tracker - [Pathway:112310] Neurotransmitter release cycle - v50:[updateIndirectRLE] [UpdateTracker:9790935] Update Tracker - [Pathway:112310] Neurotransmitter release cycle - v32:[updateContainedPathway] [UpdateTracker:9777637] Update Tracker - [Pathway:112310] Neurotransmitter release cycle - v70:[updateContainedPathway] [UpdateTracker:9788891] Update Tracker - [Pathway:112310] Neurotransmitter release cycle - v39:[updateIndirectRLE] [UpdateTracker:9781208] Update Tracker - [Pathway:112310] Neurotransmitter release cycle - v61:[updateIndirectRLE] [UpdateTracker:9791696] Update Tracker - [Pathway:112310] Neurotransmitter release cycle - v27:[addHasEvent, addLiteratureReference] [UpdateTracker:9787647] Update Tracker - [Pathway:112310] Neurotransmitter release cycle - v44:[updateIndirectRLE] [UpdateTracker:9790249] Update Tracker - [Pathway:112310] Neurotransmitter release cycle - v34:[addHasEvent] [UpdateTracker:9785387] Update Tracker - [Pathway:112310] Neurotransmitter release cycle - v52:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9776456] Update Tracker - [Pathway:112310] Neurotransmitter release cycle - v76:[updateContainedPathway] [UpdateTracker:9777949] Update Tracker - [Pathway:112310] Neurotransmitter release cycle - v68:[updateIndirectRLE] [UpdateTracker:9789971] Update Tracker - [Pathway:112310] Neurotransmitter release cycle - v36:[updateIndirectRLE] [UpdateTracker:9791748] Update Tracker - [Pathway:112310] Neurotransmitter release cycle - v26:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9842311] Update Tracker - [Pathway:112310] Neurotransmitter release cycle - v86:[updateIndirectRLE] [UpdateTracker:9791431] Update Tracker - [Pathway:112310] Neurotransmitter release cycle - v30:[updateIndirectRLE] [UpdateTracker:9790353] Update Tracker - [Pathway:112310] Neurotransmitter release cycle - v33:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9777117] Update Tracker - [Pathway:112310] Neurotransmitter release cycle - v72:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9783734] Update Tracker - [Pathway:112310] Neurotransmitter release cycle - v56:[addHasEvent, updateIndirectRLE] [UpdateTracker:9775578] Update Tracker - [Pathway:112310] Neurotransmitter release cycle - v78:[updateIndirectRLE]

Referrals

(precedingEvent)	[Pathway:R-HSA-112313] Neurotransmitter uptake and metabolism In glial cells [Pathway:R-HSA-112314] Neurotransmitter receptors and postsynaptic signal transmission [Pathway:R-HSA-112311] Neurotransmitter clearance
(hasEvent)	[Pathway:R-HSA-112315] Transmission across Chemical Synapses
(normalPathway)	[Pathway:R-HSA-5619114] Defective SLC5A7 in the neurotransmitter release cycle causes distal hereditary motor neuronopathy 7A (HMN7A)
(updatedInstance)	[UpdateTracker:9789255] Update Tracker - [Pathway:112310] Neurotransmitter release cycle - v38:[updateContainedPathway] [UpdateTracker:9786361] Update Tracker - [Pathway:112310] Neurotransmitter release cycle - v49:[updateIndirectRLE] [UpdateTracker:9785994] Update Tracker - [Pathway:112310] Neurotransmitter release cycle - v50:[updateIndirectRLE] [UpdateTracker:9790935] Update Tracker - [Pathway:112310] Neurotransmitter release cycle - v32:[updateContainedPathway] [UpdateTracker:9777637] Update Tracker - [Pathway:112310] Neurotransmitter release cycle - v70:[updateContainedPathway] [UpdateTracker:9788891] Update Tracker - [Pathway:112310] Neurotransmitter release cycle - v39:[updateIndirectRLE] [UpdateTracker:9781208] Update Tracker - [Pathway:112310] Neurotransmitter release cycle - v61:[updateIndirectRLE] [UpdateTracker:9791696] Update Tracker - [Pathway:112310] Neurotransmitter release cycle - v27:[addHasEvent, addLiteratureReference] [UpdateTracker:9787647] Update Tracker - [Pathway:112310] Neurotransmitter release cycle - v44:[updateIndirectRLE] [UpdateTracker:9790249] Update Tracker - [Pathway:112310] Neurotransmitter release cycle - v34:[addHasEvent] [UpdateTracker:9785387] Update Tracker - [Pathway:112310] Neurotransmitter release cycle - v52:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9776456] Update Tracker - [Pathway:112310] Neurotransmitter release cycle - v76:[updateContainedPathway] [UpdateTracker:9777949] Update Tracker - [Pathway:112310] Neurotransmitter release cycle - v68:[updateIndirectRLE] [UpdateTracker:9789971] Update Tracker - [Pathway:112310] Neurotransmitter release cycle - v36:[updateIndirectRLE] [UpdateTracker:9791748] Update Tracker - [Pathway:112310] Neurotransmitter release cycle - v26:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9842311] Update Tracker - [Pathway:112310] Neurotransmitter release cycle - v86:[updateIndirectRLE] [UpdateTracker:9791431] Update Tracker - [Pathway:112310] Neurotransmitter release cycle - v30:[updateIndirectRLE] [UpdateTracker:9790353] Update Tracker - [Pathway:112310] Neurotransmitter release cycle - v33:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9777117] Update Tracker - [Pathway:112310] Neurotransmitter release cycle - v72:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9783734] Update Tracker - [Pathway:112310] Neurotransmitter release cycle - v56:[addHasEvent, updateIndirectRLE] [UpdateTracker:9775578] Update Tracker - [Pathway:112310] Neurotransmitter release cycle - v78:[updateIndirectRLE]

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