PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose-1-phosphate to (deoxy)inosine

catalystActivity
catalystActivityReference [CatalystActivityReference:9643298] purine-nucleoside phosphorylase activity of NP trimer [cytosol] Characterization of purine nucleoside phosphorylase from human granulocytes and its metabolism of deoxyribonucleosides
category transition
compartment
created [InstanceEdit:112010] D'Eustachio, P, 2004-03-31 17:07:00
crossReference
dbId 112033
deleted
displayName PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose-1-phosphate to (deoxy)inosine
eventOf
input
isInDisease false
isInferred false
literatureReference
maxDepth 1
modified [InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name
  • PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose-1-phosphate to (deoxy)inosine
  • alpha-D-ribose 1-phosphate + hypoxanthine => inosine + phosphate
  • 2-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine => 2'-deoxyinosine + phosphate
  • hypoxanthine + (deoxy)ribose 1-phosphate <=> (deoxy)inosine + orthophosphate (NP)
orthologousEvent
output
releaseDate 2004-07-06
reverseReaction [Reaction:R-HSA-74242] PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose
reviewStatus [ReviewStatus:9821382] five stars
revised
schemaClass Reaction
species
stId R-HSA-112033
summation
updateTrackers
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