Reactome | Release of apoptotic factors from the mitochondria

Schema > Pathway > Entries

Release of apoptotic factors from the mitochondria Show undefined attributes

authored	[InstanceEdit:139820] Matthews, L, 2004-08-06 15:00:00
compartment	[Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:111451] Alnemri, E, 2004-02-17 00:23:30
crossReference	[DatabaseIdentifier:12819457] BioModels Database:BIOMD0000000220
dbId	111457
displayName	Release of apoptotic factors from the mitochondria
edited	[InstanceEdit:9628211] Shamovsky, Veronica, 2018-11-07
eventOf	[Pathway:R-HSA-111471] Apoptotic factor-mediated response - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-114284] Release of Cytochrome c from mitochondria - Homo sapiens [Reaction:R-HSA-114307] Release of SMAC (DIABLO) from mitochondria - Homo sapiens [Reaction:R-HSA-9627106] SMAC (DIABLO) forms dimer - Homo sapiens [BlackBoxEvent:R-HSA-6805811] Release of SEPT4 from mitochondria - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2021-03-24
literatureReference	[LiteratureReference:114481] Apoptosis-inducing factor (AIF): a ubiquitous mitochondrial oxidoreductase involved in apoptosis. [LiteratureReference:114466] Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak-mediated permeabilization. [LiteratureReference:114473] Direct interaction between survivin and Smac/DIABLO is essential for the anti-apoptotic activity of survivin during taxol-induced apoptosis. [LiteratureReference:140365] Toxic proteins released from mitochondria in cell death
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	Release of apoptotic factors from the mitochondria
orthologousEvent	[Pathway:R-PFA-111457] Release of apoptotic factors from the mitochondria - Plasmodium falciparum [Pathway:R-SCE-111457] Release of apoptotic factors from the mitochondria - Saccharomyces cerevisiae [Pathway:R-SPO-111457] Release of apoptotic factors from the mitochondria - Schizosaccharomyces pombe [Pathway:R-DDI-111457] Release of apoptotic factors from the mitochondria - Dictyostelium discoideum [Pathway:R-CEL-111457] Release of apoptotic factors from the mitochondria - Caenorhabditis elegans [Pathway:R-DME-111457] Release of apoptotic factors from the mitochondria - Drosophila melanogaster [Pathway:R-GGA-111457] Release of apoptotic factors from the mitochondria - Gallus gallus [Pathway:R-XTR-111457] Release of apoptotic factors from the mitochondria - Xenopus tropicalis [Pathway:R-DRE-111457] Release of apoptotic factors from the mitochondria - Danio rerio [Pathway:R-SSC-111457] Release of apoptotic factors from the mitochondria - Sus scrofa [Pathway:R-BTA-111457] Release of apoptotic factors from the mitochondria - Bos taurus [Pathway:R-CFA-111457] Release of apoptotic factors from the mitochondria - Canis familiaris [Pathway:R-RNO-111457] Release of apoptotic factors from the mitochondria - Rattus norvegicus [Pathway:R-MMU-111457] Release of apoptotic factors from the mitochondria - Mus musculus
releaseDate	2004-10-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:165094] Vaux, D, 0000-00-00 00:00:00
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-111457
summation	[Summation:140366] Apoptotic factors released from the mitochondria promote apo...
updateTrackers	[UpdateTracker:9776436] Update Tracker - [Pathway:111457] Release of apoptotic factors from the mitochondria - v76:[updateContainedRLE] [UpdateTracker:9778792] Update Tracker - [Pathway:111457] Release of apoptotic factors from the mitochondria - v67:[addHasEvent, addLiteratureReference, updateContainedRLE] [UpdateTracker:9787904] Update Tracker - [Pathway:111457] Release of apoptotic factors from the mitochondria - v44:[updateContainedRLE] [UpdateTracker:9780491] Update Tracker - [Pathway:111457] Release of apoptotic factors from the mitochondria - v63:[updateContainedRLE]

Referrals

(updatedInstance)

[UpdateTracker:9776436] Update Tracker - [Pathway:111457] Release of apoptotic factors from the mitochondria - v76:[updateContainedRLE]
[UpdateTracker:9778792] Update Tracker - [Pathway:111457] Release of apoptotic factors from the mitochondria - v67:[addHasEvent, addLiteratureReference, updateContainedRLE]
[UpdateTracker:9787904] Update Tracker - [Pathway:111457] Release of apoptotic factors from the mitochondria - v44:[updateContainedRLE]
[UpdateTracker:9780491] Update Tracker - [Pathway:111457] Release of apoptotic factors from the mitochondria - v63:[updateContainedRLE]

(hasEvent)

[Pathway:R-HSA-111471] Apoptotic factor-mediated response

Cite Us!