Release of apoptotic factors from the mitochondria

Stable Identifier
R-HSA-111457
Type
Pathway
Species
Homo sapiens
Compartment
mitochondrial outer membrane
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Release of apoptotic factors from the mitochondria
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Apoptotic factors released from the mitochondria promote apoptosis through several different mechanisms. Cytochrome C participates in Apoptosome driven effector caspase activation while SMAC relieves IAP mediated caspase inhibition.

Literature References
PubMed ID Title Journal Year
15077149 Toxic proteins released from mitochondria in cell death

van Loo, G, van Gurp, M, Vandenabeele, P, Saelens, X, Vande Walle, L, Festjens, N

Oncogene 2004
12660240 Direct interaction between survivin and Smac/DIABLO is essential for the anti-apoptotic activity of survivin during taxol-induced apoptosis.

Song, Z, Wu, M, Yao, X

J Biol Chem 2003
12941691 Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak-mediated permeabilization.

Arnoult, D, Karbowski, M, Gaume, B, Cecconi, F, Sharpe, JC, Youle, RJ

EMBO J 2003
10913597 Apoptosis-inducing factor (AIF): a ubiquitous mitochondrial oxidoreductase involved in apoptosis.

Kroemer, G, Loeffler, M, Ravagnan, L, Zamzami, N, Susin, SA, Nochy, D, Daugas, E

FEBS Lett 2000
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Orthologous Events
Release of apoptotic factors from the mitochondria (Bos taurus)
Release of apoptotic factors from the mitochondria (Caenorhabditis elegans)
Release of apoptotic factors from the mitochondria (Canis familiaris)
Release of apoptotic factors from the mitochondria (Danio rerio)
Release of apoptotic factors from the mitochondria (Dictyostelium discoideum)
Release of apoptotic factors from the mitochondria (Drosophila melanogaster)
Release of apoptotic factors from the mitochondria (Gallus gallus)
Release of apoptotic factors from the mitochondria (Mus musculus)
Release of apoptotic factors from the mitochondria (Plasmodium falciparum)
Release of apoptotic factors from the mitochondria (Rattus norvegicus)
Release of apoptotic factors from the mitochondria (Saccharomyces cerevisiae)
Release of apoptotic factors from the mitochondria (Schizosaccharomyces pombe)
Release of apoptotic factors from the mitochondria (Sus scrofa)
Release of apoptotic factors from the mitochondria (Xenopus tropicalis)
Cross References
BioModels Database
Authored
Matthews, L  (2004-08-06)
Reviewed
Vaux, DL  (2022-03-10)
Created
Alnemri, E  (2004-02-17)
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