Apoptotic factors released from the mitochondria promote apoptosis through several different mechanisms. Cytochrome C participates in Apoptosome driven effector caspase activation while SMAC relieves IAP mediated caspase inhibition.
Song, Z, Yao, X, Wu, M
Saelens, X, Festjens, N, Vande Walle, L, van Gurp, M, van Loo, G, Vandenabeele, P
Arnoult, D, Gaume, B, Karbowski, M, Sharpe, JC, Cecconi, F, Youle, RJ
Daugas, E, Nochy, D, Ravagnan, L, Loeffler, M, Susin, SA, Zamzami, N, Kroemer, G
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