Reactome | Release of apoptotic factors from the mitochondria

Release of apoptotic factors from the mitochondria

Stable Identifier

R-HSA-111457

Type

Pathway

Species

Homo sapiens

Compartment

mitochondrial outer membrane

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Release of apoptotic factors from the mitochondria

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Apoptotic factors released from the mitochondria promote apoptosis through several different mechanisms. Cytochrome C participates in Apoptosome driven effector caspase activation while SMAC relieves IAP mediated caspase inhibition.

Literature References

PubMed ID	Title	Journal	Year
12660240	Direct interaction between survivin and Smac/DIABLO is essential for the anti-apoptotic activity of survivin during taxol-induced apoptosis. Song, Z, Yao, X, Wu, M	J Biol Chem	2003
15077149	Toxic proteins released from mitochondria in cell death Saelens, X, Festjens, N, Vande Walle, L, van Gurp, M, van Loo, G, Vandenabeele, P	Oncogene	2004
12941691	Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak-mediated permeabilization. Arnoult, D, Gaume, B, Karbowski, M, Sharpe, JC, Cecconi, F, Youle, RJ	EMBO J	2003
10913597	Apoptosis-inducing factor (AIF): a ubiquitous mitochondrial oxidoreductase involved in apoptosis. Daugas, E, Nochy, D, Ravagnan, L, Loeffler, M, Susin, SA, Zamzami, N, Kroemer, G	FEBS Lett	2000