Release of apoptotic factors from the mitochondria

Stable Identifier
R-HSA-111457
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Pathway
Species
Homo sapiens
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Apoptotic factors released from the mitochondria promote apoptosis through several different mechanisms. Cytochrome C participates in Apoptosome driven effector caspase activation while SMAC relieves IAP mediated caspase inhibition.

Literature References
PubMed ID Title Journal Year
15077149 Toxic proteins released from mitochondria in cell death

van Loo, G, van Gurp, M, Vandenabeele, P, Saelens, X, Vande Walle, L, Festjens, N

Oncogene 2004
12660240 Direct interaction between survivin and Smac/DIABLO is essential for the anti-apoptotic activity of survivin during taxol-induced apoptosis.

Song, Z, Wu, M, Yao, X

J Biol Chem 2003
12941691 Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak-mediated permeabilization.

Arnoult, D, Karbowski, M, Gaume, B, Cecconi, F, Sharpe, JC, Youle, RJ

EMBO J 2003
10913597 Apoptosis-inducing factor (AIF): a ubiquitous mitochondrial oxidoreductase involved in apoptosis.

Kroemer, G, Loeffler, M, Ravagnan, L, Zamzami, N, Susin, SA, Nochy, D, Daugas, E

FEBS Lett 2000
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