Reactome | Formation of phosphoribosyl pyrophosphate amidotransferase tetramer

Formation of phosphoribosyl pyrophosphate amidotransferase tetramer

Stable Identifier

R-HSA-111285

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

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Formation of phosphoribosyl pyrophosphate amidotransferase tetramer

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Cytosolic AMP, GMP, and IMP stimulate the association of phosphoribosyl pyrophosphate amidotransferase (PPAT) dimers to form tetramers (Holmes et al. 1973a,b).

Literature References

PubMed ID	Title	Journal	Year
4726295	Human glutamine phosphoribosylpyrophosphate amidotransferase. Two molecular forms interconvertible by purine ribonucleotides and phosphoribosylpyrophosphate Holmes, EW, Wyngaarden, JB, Kelley, WN	J Biol Chem	1973
4348202	Human glutamine phosphoribosylpyrophosphate amidotransferase. Kinetic and regulatory properties Holmes, EW, McDonald, JA, McCord, JM, Wyngaarden, JB, Kelley, WN	J Biol Chem	1973