Reactome | Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane]

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Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] Show undefined attributes

catalystActivities	[CatalystActivity:1363334] non-membrane spanning protein tyrosine kinase activity of Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane]
compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-1112744] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11:CBL [plasma membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-1112703] PTPN11 is phosphorylated - Homo sapiens [Reaction:R-HSA-1112690] PTPN11 binds CBL - Homo sapiens
created	[InstanceEdit:1112700] Jupe, S, 2010-12-10
dbId	1112758
displayName	Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane]
hasComponent	[EntityWithAccessionedSequence:R-HSA-162563] PTPN11 [cytosol] [Complex:R-HSA-1112594] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane]
inDisease	false
includedLocation	[Compartment:70101] cytosol
inferredTo	[Complex:R-MMU-1112758] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] - Mus musculus [Complex:R-RNO-1112758] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] - Rattus norvegicus [Complex:R-CFA-1112758] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] - Canis familiaris [Complex:R-BTA-1112758] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] - Bos taurus [Complex:R-SSC-1112758] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] - Sus scrofa [Complex:R-DRE-1112758] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] - Danio rerio [Complex:R-XTR-1112758] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] - Xenopus tropicalis [Complex:R-GGA-1112758] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] - Gallus gallus
isChimeric	false
maxDepth	7
modified	[InstanceEdit:8963884] Jupe, Steve, 2017-02-13
name	Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11
producedByEvent	[Reaction:R-HSA-1112708] PTPN11 binds p-Y759-IL6ST - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-1112758
updateTrackers	[UpdateTracker:9877553] Update Tracker - [Complex:1112758] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] - v44:[updateContainedComponent] [UpdateTracker:9896742] Update Tracker - [Complex:1112758] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] - v60:[modifyName, updateContainedComponent] [UpdateTracker:9871076] Update Tracker - [Complex:1112758] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] - v39:[modifyName, updateContainedComponent]

Referrals

(updatedInstance)	[UpdateTracker:9877553] Update Tracker - [Complex:1112758] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] - v44:[updateContainedComponent] [UpdateTracker:9896742] Update Tracker - [Complex:1112758] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] - v60:[modifyName, updateContainedComponent] [UpdateTracker:9871076] Update Tracker - [Complex:1112758] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] - v39:[modifyName, updateContainedComponent]
(input)	[Reaction:R-HSA-1112703] PTPN11 is phosphorylated [Reaction:R-HSA-1112690] PTPN11 binds CBL
(physicalEntity)	[CatalystActivity:1363334] non-membrane spanning protein tyrosine kinase activity of Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane]
(hasComponent)	[Complex:R-HSA-1112744] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11:CBL [plasma membrane]
(output)	[Reaction:R-HSA-1112708] PTPN11 binds p-Y759-IL6ST

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