Reactome | PTPN11 is phosphorylated

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PTPN11 is phosphorylated Show undefined attributes

authored	[InstanceEdit:1164950] Ray, K, 2010-12-13
catalystActivity	[CatalystActivity:1363334] non-membrane spanning protein tyrosine kinase activity of Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:1112700] Jupe, S, 2010-12-10
dbId	1112703
displayName	PTPN11 is phosphorylated
edited	[InstanceEdit:1112767] Jupe, S, 2010-12-10
eventOf	[Pathway:R-HSA-1059683] Interleukin-6 signaling - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-1112758] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1112730] Activation of the protein tyrosine phosphatase SHP2 via the interleukin-6 signal transducing receptor protein gp130 requires tyrosine kinase Jak1 and limits acute-phase protein expression
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	PTPN11 is phosphorylated
orthologousEvent	[Reaction:R-SSC-1112703] PTPN11 is phosphorylated - Sus scrofa [Reaction:R-GGA-1112703] PTPN11 is phosphorylated - Gallus gallus [Reaction:R-XTR-1112703] PTPN11 is phosphorylated - Xenopus tropicalis [Reaction:R-DRE-1112703] PTPN11 is phosphorylated - Danio rerio [Reaction:R-BTA-1112703] PTPN11 is phosphorylated - Bos taurus [Reaction:R-CFA-1112703] PTPN11 is phosphorylated - Canis familiaris [Reaction:R-RNO-1112703] PTPN11 is phosphorylated - Rattus norvegicus [Reaction:R-MMU-1112703] PTPN11 is phosphorylated - Mus musculus
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-1112753] IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane]
precedingEvent	[Reaction:R-HSA-1112708] PTPN11 binds p-Y759-IL6ST - Homo sapiens
releaseDate	2011-03-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1214159] Rose-John, S, 2011-02-11
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1112703
summation	[Summation:1112756] PTPN11 (SHP2) is tyrosine-phosphorylated in a JAK1-dependent...
updateTrackers	[UpdateTracker:9781752] Update Tracker - [Reaction:1112703] PTPN11 is phosphorylated - v60:[modifyText] [UpdateTracker:9789390] Update Tracker - [Reaction:1112703] PTPN11 is phosphorylated - v38:[addCatalystActivity, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9781752] Update Tracker - [Reaction:1112703] PTPN11 is phosphorylated - v60:[modifyText] [UpdateTracker:9789390] Update Tracker - [Reaction:1112703] PTPN11 is phosphorylated - v38:[addCatalystActivity, modifyText]
(hasEvent)	[Pathway:R-HSA-1059683] Interleukin-6 signaling