Reactome | Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane]

Schema > Complex > Entries

catalystActivities	[CatalystActivity:10768806] non-membrane spanning protein tyrosine kinase activity of Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane]
compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-GGA-1112744] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11:CBL [plasma membrane] - Gallus gallus
consumedByEvent	[Reaction:R-GGA-1112703] PTPN11 is phosphorylated - Gallus gallus [Reaction:R-GGA-1112690] PTPN11 binds CBL - Gallus gallus
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10768799
displayName	Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane]
hasComponent	[EntityWithAccessionedSequence:R-GGA-162563] PTPN11 [cytosol] [Complex:R-GGA-1112594] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane]
inDisease	false
inferredFrom	[Complex:R-HSA-1112758] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] - Homo sapiens
maxDepth	7
name	Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11
producedByEvent	[Reaction:R-GGA-1112708] PTPN11 binds p-Y759-IL6ST - Gallus gallus
schemaClass	Complex
species	[Species:49591] Gallus gallus
stId	R-GGA-1112758
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(input)	[Reaction:R-GGA-1112703] PTPN11 is phosphorylated [Reaction:R-GGA-1112690] PTPN11 binds CBL
(physicalEntity)	[CatalystActivity:10768806] non-membrane spanning protein tyrosine kinase activity of Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane]
(hasComponent)	[Complex:R-GGA-1112744] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11:CBL [plasma membrane]
(output)	[Reaction:R-GGA-1112708] PTPN11 binds p-Y759-IL6ST
(inferredTo)	[Complex:R-HSA-1112758] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane]

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