Reactome | Cleavage of adenine mispaired with 8-oxoguanine by MUTYH

Schema > Reaction > Entries

Cleavage of adenine mispaired with 8-oxoguanine by MUTYH Show undefined attributes

catalystActivity	[CatalystActivity:10566546] DNA N-glycosylase activity of MUTYH:(8oxoG:Ade)-dsDNA [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10566548
displayName	Cleavage of adenine mispaired with 8-oxoguanine by MUTYH
eventOf	[Pathway:R-DRE-110331] Cleavage of the damaged purine - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-110355] Displacement of MUTYH glycosylase by APEX1 at the AP site - Danio rerio
inferredFrom	[Reaction:R-HSA-110246] Cleavage of adenine mispaired with 8-oxoguanine by MUTYH - Homo sapiens
input	[Complex:R-DRE-110199] MUTYH:(8oxoG:Ade)-dsDNA [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Cleavage of adenine mispaired with 8-oxoguanine by MUTYH
output	[SimpleEntity:R-ALL-5635947] Ade [nucleoplasm] [Complex:R-DRE-110200] MUTYH:AP-dsDNA [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-110246
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-DRE-110355] Displacement of MUTYH glycosylase by APEX1 at the AP site
(hasEvent)	[Pathway:R-DRE-110331] Cleavage of the damaged purine
(inferredTo)	[Reaction:R-HSA-110246] Cleavage of adenine mispaired with 8-oxoguanine by MUTYH

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