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Schema
>
Reaction
>
Entries
deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2]
Show undefined attributes
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catalystActivity
[CatalystActivity:109753] nucleoside kinase activity of TK2 [mitochondrial matrix]
category
transition
compartment
[Compartment:5460] mitochondrial matrix
created
[InstanceEdit:109746] D'Eustachio, P, 2004-01-20 14:32:00
crossReference
[DatabaseIdentifier:9976239] RHEA:46041
[DatabaseIdentifier:9976252] RHEA:19130
[DatabaseIdentifier:9976250] RHEA:28207
dbId
109759
deleted
[Deleted:500825] Deletion of instances: 109756, 109755, 109754
displayName
deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2]
eventOf
[Pathway:R-HSA-73614] Pyrimidine salvage - Homo sapiens
input
[SimpleEntity:R-ALL-113593] ATP [mitochondrial matrix]
[DefinedSet:R-ALL-500822] dC, Thy-dRib, dU [mitochondrial matrix]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:109744] Mammalian thymidine kinase 2. Direct photoaffinity labeling with [32P]dTTP of the enzyme from spleen, liver, heart and brain
[LiteratureReference:109764] Human deoxythymidine kinase. I. Purification and general properties of the cytoplasmic and mitochondrial isozymes derived from blast cells of acute myelocytic leukemia
[LiteratureReference:109747] Diverging substrate specificity of pure human thymidine kinases 1 and 2 against antiviral dideoxynucleosides
[LiteratureReference:109750] Human thymidine kinase 2: molecular cloning and characterisation of the enzyme activity with antiviral and cytostatic nucleoside substrates
maxDepth
1
modified
[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name
deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2]
2'-deoxycytidine + ATP => dCMP + ADP + H(+)
thymidine + ATP => dTMP + ADP + H(+)
2'-deoxyuridine + ATP => dUMP + ADP + H(+)
orthologousEvent
[Reaction:R-MMU-109759] deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] - Mus musculus
[Reaction:R-DDI-109759] deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] - Dictyostelium discoideum
[Reaction:R-DME-109759] deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] - Drosophila melanogaster
[Reaction:R-GGA-109759] deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] - Gallus gallus
[Reaction:R-XTR-109759] deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] - Xenopus tropicalis
[Reaction:R-DRE-109759] deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] - Danio rerio
[Reaction:R-SSC-109759] deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] - Sus scrofa
[Reaction:R-BTA-109759] deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] - Bos taurus
[Reaction:R-CFA-109759] deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] - Canis familiaris
[Reaction:R-RNO-109759] deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] - Rattus norvegicus
output
[SimpleEntity:R-ALL-113581] ADP [mitochondrial matrix]
[DefinedSet:R-ALL-500823] dCMP, TMP, dUMP [mitochondrial matrix]
[SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix]
previousReviewStatus
[ReviewStatus:9821385] four stars
releaseDate
2004-07-06
releaseStatus
UPDATED
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9977064] D'Eustachio, Peter, 2025-12-16
revised
[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-109759
summation
[Summation:178275] Mitochondrial thymidine kinase 2 (TK2) catalyzes the reactio...
updateTrackers
[UpdateTracker:9790845] Update Tracker - [Reaction:109759] deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] - v32:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText]
[UpdateTracker:9984637] Update Tracker - [Reaction:109759] deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] - v96:[removeOutput]
Referrals
(updatedInstance)
[UpdateTracker:9790845] Update Tracker - [Reaction:109759] deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] - v32:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText]
[UpdateTracker:9984637] Update Tracker - [Reaction:109759] deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] - v96:[removeOutput]
(replacementInstances)
[Deleted:500825] Deletion of instances: 109756, 109755, 109754
(hasEvent)
[Pathway:R-HSA-73614] Pyrimidine salvage
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