Reactome | Activated TLR5/TLR15 homodimer recruits MyD88 adaptor

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Activated TLR5/TLR15 homodimer recruits MyD88 adaptor Show undefined attributes

authored	[InstanceEdit:1094913] Shamovsky, V, 2010-11-30
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:977249] Shamovsky, V, 2010-10-15
dbId	977238
displayName	Activated TLR5/TLR15 homodimer recruits MyD88 adaptor
edited	[InstanceEdit:1221606] Shamovsky, V, 2011-02-24
eventOf	[Pathway:R-GGA-977240] MyD88 cascade initiated on plasma membrane - Gallus gallus
followingEvent	[Reaction:R-GGA-434130] IRAK4 binds to activated TLR5 or 15 - Gallus gallus
input	[DefinedSet:R-GGA-977246] activated TLR5 or 15 bound to ligand [plasma membrane] 2 × [EntityWithAccessionedSequence:R-GGA-433987] MyD88 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:571177] Molecular cloning and functional characterization of a novel isoform of chicken myeloid differentiation factor 88 (MyD88) [LiteratureReference:166234] The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors [LiteratureReference:571295] Identification of critical residues of the MyD88 death domain involved in the recruitment of downstream kinases
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activated TLR5/TLR15 homodimer recruits MyD88 adaptor
output	[Complex:R-GGA-977241] activated TLR homodimer : MyD88 complex [plasma membrane]
precedingEvent	[Reaction:R-GGA-451474] Bacterial Flagellin binds TLR5 homodimer - Gallus gallus [Reaction:R-GGA-451511] TLR15 binds to recognized ligand - Gallus gallus
relatedSpecies	[Species:451465] Salmonella typhimurium
releaseDate	2011-03-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1112618] D'Eustachio, P, 2010-12-06
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-977238
summation	[Summation:571170] Cloning and analysis of full length chicken MyD88 revealed a...

Referrals

(hasEvent)	[Pathway:R-GGA-977240] MyD88 cascade initiated on plasma membrane
(precedingEvent)	[Reaction:R-GGA-434130] IRAK4 binds to activated TLR5 or 15

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