Reactome | TLR15 binds to recognized ligand

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TLR15 binds to recognized ligand Show undefined attributes

authored	[InstanceEdit:1094913] Shamovsky, V, 2010-11-30
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:451501] Shamovsky, V, 2010-01-05
dbId	451511
displayName	TLR15 binds to recognized ligand
edited	[InstanceEdit:1221606] Shamovsky, V, 2011-02-24
eventOf	[Pathway:R-GGA-451529] TLR15 cascade - Gallus gallus
followingEvent	[Reaction:R-GGA-977238] Activated TLR5/TLR15 homodimer recruits MyD88 adaptor - Gallus gallus
input	[OtherEntity:R-ALL-451479] Ligand recognized by chicken TLR15 [extracellular region] 2 × [EntityWithAccessionedSequence:R-GGA-451532] TLR15 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1216461] Induction of a novel chicken Toll-like receptor following Salmonella enterica serovar Typhimurium infection [LiteratureReference:1216479] Expression of the avian-specific toll-like receptor 15 in chicken heterophils is mediated by gram-negative and gram-positive bacteria, but not TLR agonists [LiteratureReference:1216465] Avian-specific TLRs and downstream effector responses to CpG-induction in chicken macrophages [LiteratureReference:2532775] Cleavage and activation of a Toll-like receptor by microbial proteases [LiteratureReference:2532765] TLR15 Is Unique to Avian and Reptilian Lineages and Recognizes a Yeast-Derived Agonist [LiteratureReference:1216490] Unique genome-wide transcriptome profiles of chicken macrophages exposed to Salmonella-derived endotoxin
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TLR15 binds to recognized ligand
output	[Complex:R-GGA-451519] TLR15 bound to recognized ligand [plasma membrane]
releaseDate	2011-03-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1112618] D'Eustachio, P, 2010-12-06
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-451511
summation	[Summation:1216495] TLR15 induction was observed in chicken embryonic fibroblast...
updateTrackers	[UpdateTracker:9786870] Update Tracker - [Reaction:451511] TLR15 binds to recognized ligand - v47:[modifyText] [UpdateTracker:9788214] Update Tracker - [Reaction:451511] TLR15 binds to recognized ligand - v43:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9786870] Update Tracker - [Reaction:451511] TLR15 binds to recognized ligand - v47:[modifyText] [UpdateTracker:9788214] Update Tracker - [Reaction:451511] TLR15 binds to recognized ligand - v43:[addLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-GGA-451529] TLR15 cascade
(precedingEvent)	[Reaction:R-GGA-977238] Activated TLR5/TLR15 homodimer recruits MyD88 adaptor