Reactome | Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin

Schema > BlackBoxEvent > Entries

Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin Show undefined attributes

catalystActivity	[CatalystActivity:9908094] oxidoreductase activity of Protein [cytosol]
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10819380
displayName	Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin
eventOf	[Pathway:R-GGA-9759218] Cobalamin (Cbl) metabolism - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-3149494] MMACHC:cob(II)alamin binds MMADHC - Gallus gallus
inferredFrom	[BlackBoxEvent:R-HSA-9759549] Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin - Homo sapiens
input	[SimpleEntity:R-ALL-70106] H+ [cytosol] 2 × [Complex:R-GGA-9759561] MMACHC:cob(I)alamin [cytosol] [SimpleEntity:R-ALL-29360] NAD+ [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin 2 cob(I)alamin + H(+) + NAD(+) => 2 cob(II)alamin + NADH
output	2 × [Complex:R-GGA-3095903] MMACHC:cob(II)alamin [cytosol] [SimpleEntity:R-ALL-73473] NADH [cytosol]
precedingEvent	[Reaction:R-GGA-3095889] MMACHC dealkylates RCbl - Gallus gallus
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:49591] Gallus gallus
stId	R-GGA-9759549
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-9759218] Cobalamin (Cbl) metabolism
(precedingEvent)	[Reaction:R-GGA-3149494] MMACHC:cob(II)alamin binds MMADHC
(inferredTo)	[BlackBoxEvent:R-HSA-9759549] Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin

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