Reactome | Cobalamin (Cbl) metabolism

Schema > Pathway > Entries

Cobalamin (Cbl) metabolism Show undefined attributes

created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10826063
displayName	Cobalamin (Cbl) metabolism
eventOf	[Pathway:R-GGA-196741] Cobalamin (Cbl, vitamin B12) transport and metabolism - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:8737] cobalamin metabolic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-GGA-3095889] MMACHC dealkylates RCbl - Gallus gallus [BlackBoxEvent:R-GGA-9759549] Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin - Gallus gallus [Reaction:R-GGA-3149519] MMACHC decyanates CNCbl - Gallus gallus [Reaction:R-GGA-3149494] MMACHC:cob(II)alamin binds MMADHC - Gallus gallus [BlackBoxEvent:R-GGA-3204318] cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR - Gallus gallus [Reaction:R-GGA-3149518] MTRR reduces cob(II)alamin to meCbl - Gallus gallus [Reaction:R-GGA-174374] MTR transfers CH3 from MeCbl to HCYS - Gallus gallus [Reaction:R-GGA-3149539] MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin - Gallus gallus [Reaction:R-GGA-3149563] MMADHC targets transport of cytosolic cob(II)alamin to mitochondria - Gallus gallus [Reaction:R-GGA-3159253] MMAB adenosylates cob(I)alamin - Gallus gallus [Reaction:R-GGA-3159259] MMAA:MUT binds AdoCbl - Gallus gallus
inferredFrom	[Pathway:R-HSA-9759218] Cobalamin (Cbl) metabolism - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Cobalamin (Cbl) metabolism
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49591] Gallus gallus
stId	R-GGA-9759218
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-196741] Cobalamin (Cbl, vitamin B12) transport and metabolism
(inferredTo)	[Pathway:R-HSA-9759218] Cobalamin (Cbl) metabolism

© 2026 Reactome

Cite Us!