Reactome | Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin

Schema > BlackBoxEvent > Entries

Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin Show undefined attributes

authored	[InstanceEdit:196747] Jassal, B, 2007-04-24 08:38:46
catalystActivity	[CatalystActivity:9908094] oxidoreductase activity of Protein [cytosol]
catalystActivityReference	[CatalystActivityReference:9908089] oxidoreductase activity of Protein [cytosol] Enzymatic conversion of vitamin B 12a to adenosyl-B 12: evidence for the existence of two separate reducing systems
category	uncertain
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9759552] D'Eustachio, Peter, 2021-12-06
crossReference	[DatabaseIdentifier:9908097] RHEA:17482
dbId	9759549
displayName	Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin
edited	[InstanceEdit:9759552] D'Eustachio, Peter, 2021-12-06
eventOf	[Pathway:R-HSA-9759218] Cobalamin (Cbl) metabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-3149494] MMACHC:cob(II)alamin binds MMADHC - Homo sapiens
input	[SimpleEntity:R-ALL-70106] H+ [cytosol] 2 × [Complex:R-HSA-9759561] MMACHC:cob(I)alamin [cytosol] [SimpleEntity:R-ALL-29360] NAD+ [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9758714] Redox-Linked Coordination Chemistry Directs Vitamin B₁₂ Trafficking [LiteratureReference:9759550] Enzymatic conversion of vitamin B 12a to adenosyl-B 12: evidence for the existence of two separate reducing systems
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin 2 cob(I)alamin + H(+) + NAD(+) => 2 cob(II)alamin + NADH
orthologousEvent	[BlackBoxEvent:R-XTR-9759549] Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin - Xenopus tropicalis [BlackBoxEvent:R-DDI-9759549] Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin - Dictyostelium discoideum [BlackBoxEvent:R-CEL-9759549] Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin - Caenorhabditis elegans [BlackBoxEvent:R-GGA-9759549] Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin - Gallus gallus [BlackBoxEvent:R-DRE-9759549] Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin - Danio rerio [BlackBoxEvent:R-SSC-9759549] Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin - Sus scrofa [BlackBoxEvent:R-BTA-9759549] Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin - Bos taurus [BlackBoxEvent:R-CFA-9759549] Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin - Canis familiaris [BlackBoxEvent:R-RNO-9759549] Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin - Rattus norvegicus [BlackBoxEvent:R-MMU-9759549] Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin - Mus musculus
output	2 × [Complex:R-HSA-3095903] MMACHC:cob(II)alamin [cytosol] [SimpleEntity:R-ALL-73473] NADH [cytosol]
precedingEvent	[Reaction:R-HSA-3095889] MMACHC dealkylates RCbl - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2022-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9764895] Hill, David P, 2022-02-14 [InstanceEdit:9916041] Hill, David P, 2024-07-19
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9759549
summation	[Summation:9759556] Cob(I)alamin bound to MMACHC (Methylmalonic aciduria and hom...
updateTrackers	[UpdateTracker:9911025] Update Tracker - [BlackBoxEvent:9759549] Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin - v89:[addCatalystActivity, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9911025] Update Tracker - [BlackBoxEvent:9759549] Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin - v89:[addCatalystActivity, modifyText]
(precedingEvent)	[NegativePrecedingEvent:9764890] Abundant Molecules: Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin [Reaction:R-HSA-3149494] MMACHC:cob(II)alamin binds MMADHC
(hasEvent)	[Pathway:R-HSA-9759218] Cobalamin (Cbl) metabolism