Reactome | SUCLG1/A2 cleaves succinyl-CoA

Schema > Reaction > Entries

SUCLG1/A2 cleaves succinyl-CoA Show undefined attributes

catalystActivity	[CatalystActivity:10734096] succinate-CoA ligase (ADP-forming) activity of SUCLA2:SUCLG1 [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10734098
displayName	SUCLG1/A2 cleaves succinyl-CoA
eventOf	[Pathway:R-GGA-71403] Citric acid cycle (TCA cycle) - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-70994] SDH complex dehydrogenates succinate - Gallus gallus
inferredFrom	[Reaction:R-HSA-70997] SUCLG1/A2 cleaves succinyl-CoA - Homo sapiens
input	[SimpleEntity:R-ALL-113581] ADP [mitochondrial matrix] [SimpleEntity:R-ALL-113548] Pi [mitochondrial matrix] [SimpleEntity:R-ALL-70958] SUCC-CoA [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	SUCLG1/A2 cleaves succinyl-CoA ADP + phosphate + succinyl-CoA => ATP + CoA + succinate
output	[SimpleEntity:R-ALL-113593] ATP [mitochondrial matrix] [SimpleEntity:R-ALL-29374] CoA-SH [mitochondrial matrix] [SimpleEntity:R-ALL-113536] SUCCA [mitochondrial matrix]
precedingEvent	[Reaction:R-GGA-71401] OGDH dimer decarboxylates 2-OG - Gallus gallus [Reaction:R-GGA-71010] MUT isomerises L-MM-CoA to SUCC-CoA - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-70997
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-71403] Citric acid cycle (TCA cycle)
(precedingEvent)	[Reaction:R-GGA-70994] SDH complex dehydrogenates succinate
(inferredTo)	[Reaction:R-HSA-70997] SUCLG1/A2 cleaves succinyl-CoA

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