Reactome | IL4R binds JAK2

Schema > Reaction > Entries

category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10798536
displayName	IL4R binds JAK2
eventOf	[Pathway:R-GGA-6785807] Interleukin-4 and Interleukin-13 signaling - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-6786101] IL4 binds IL4R:JAK2 - Gallus gallus
inferredFrom	[Reaction:R-HSA-6785898] IL4R binds JAK2 - Homo sapiens
input	[EntityWithAccessionedSequence:R-GGA-449670] IL4R [plasma membrane] [EntityWithAccessionedSequence:R-GGA-210620] JAK2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	IL4R binds JAK2
output	[Complex:R-GGA-6785800] IL4R:JAK2 [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-6785898
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-GGA-6785807] Interleukin-4 and Interleukin-13 signaling
(precedingEvent)	[Reaction:R-GGA-6786101] IL4 binds IL4R:JAK2
(inferredTo)	[Reaction:R-HSA-6785898] IL4R binds JAK2