Reactome | PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate

Schema > Reaction > Entries

PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate Show undefined attributes

catalystActivity	[CatalystActivity:10798237] proline dehydrogenase activity of PRODH2 dimer [mitochondrial inner membrane]
category	transition
compartment	[Compartment:5460] mitochondrial matrix [Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10798239
displayName	PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate
eventOf	[Pathway:R-GGA-389661] Glyoxylate metabolism and glycine degradation - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-6784402] ALDH4A1 converts 1PYR-3OH-5COOH to 4-OH-L-glutamate - Gallus gallus
goBiologicalProcess	[GO_BiologicalProcess:15010] glyoxylate metabolic process
inferredFrom	[Reaction:R-HSA-6784224] PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate - Homo sapiens
input	[SimpleEntity:R-ALL-6784215] HPRO [mitochondrial matrix] [SimpleEntity:R-ALL-9930628] quinone [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate a quinone + trans-4-hydroxy-L-proline => (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+)
output	[SimpleEntity:R-ALL-9929425] 1PYR-3OH-5COOH [mitochondrial matrix] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-9930630] quinol [mitochondrial matrix]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-6784224
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-389661] Glyoxylate metabolism and glycine degradation
(precedingEvent)	[Reaction:R-GGA-6784402] ALDH4A1 converts 1PYR-3OH-5COOH to 4-OH-L-glutamate
(inferredTo)	[Reaction:R-HSA-6784224] PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate

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