Reactome | 5-MCDG [nucleoplasm]

Schema > EntityWithAccessionedSequence > Entries

catalystActivities	[CatalystActivity:10788471] DNA N-glycosylase activity of TDG [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-GGA-110190] TDG:EtCYT-dsDNA [nucleoplasm] - Gallus gallus [Complex:R-GGA-110155] TDG:(Ura:Gua)-dsDNA [nucleoplasm] - Gallus gallus
consumedByEvent	[Reaction:R-GGA-4551738] SUMOylation of TDG with SUMO2,3 - Gallus gallus [Reaction:R-GGA-4551648] SUMOylation of TDG with SUMO1 - Gallus gallus [Reaction:R-GGA-5221061] TDG excises 5-carboxylcytosine - Gallus gallus [Reaction:R-GGA-5220959] TDG excises 5-formylcytosine - Gallus gallus
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10738204
displayName	5-MCDG [nucleoplasm]
endCoordinate	410
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-65812] TDG [nucleoplasm] - Homo sapiens
maxDepth	1
name	5-MCDG TDG Q9PUA4
referenceEntity	[ReferenceGeneProduct:uniprot:Q9PUA4] UniProt:Q9PUA4 5-MCDG
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:49591] Gallus gallus
stId	R-GGA-65812
startCoordinate	1

(input)	[Reaction:R-GGA-4551738] SUMOylation of TDG with SUMO2,3 [Reaction:R-GGA-4551648] SUMOylation of TDG with SUMO1 [Reaction:R-GGA-5221061] TDG excises 5-carboxylcytosine [Reaction:R-GGA-5220959] TDG excises 5-formylcytosine
(physicalEntity)	[CatalystActivity:10788471] DNA N-glycosylase activity of TDG [nucleoplasm]
(activeUnit)	[CatalystActivity:10738314] DNA N-glycosylase activity of TDG:EtCYT-dsDNA [nucleoplasm] [CatalystActivity:10738239] DNA N-glycosylase activity of TDG:(Ura:Gua)-dsDNA [nucleoplasm] [CatalystActivity:10738246] DNA N-glycosylase activity of TDG:(T:G)-dsDNA [nucleoplasm]
(hasComponent)	[Complex:R-GGA-110190] TDG:EtCYT-dsDNA [nucleoplasm] [Complex:R-GGA-110155] TDG:(Ura:Gua)-dsDNA [nucleoplasm] [Complex:R-GGA-110191] TDG:AP-dsDNA [nucleoplasm] [Complex:R-GGA-110150] TDG:(T:G)-dsDNA [nucleoplasm]
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-65812] TDG [nucleoplasm]