Reactome | TDG excises 5-formylcytosine

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TDG excises 5-formylcytosine Show undefined attributes

catalystActivity	[CatalystActivity:10788471] DNA N-glycosylase activity of TDG [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10788473
displayName	TDG excises 5-formylcytosine
eventOf	[Pathway:R-GGA-5221030] TET1,2,3 and TDG demethylate DNA - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:9907540] chromosomal 5-methylcytosine DNA demethylation, oxidation pathway
inferredFrom	[Reaction:R-HSA-5220959] TDG excises 5-formylcytosine - Homo sapiens
input	[EntityWithAccessionedSequence:R-GGA-65812] 5-MCDG [nucleoplasm] [OtherEntity:R-ALL-5221062] DNA containing 5-fC [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	TDG excises 5-formylcytosine
output	[SimpleEntity:R-ALL-5221065] 5-fC [nucleoplasm] [Complex:R-GGA-110191] TDG:AP-dsDNA [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-5220959
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-5221030] TET1,2,3 and TDG demethylate DNA
(inferredTo)	[Reaction:R-HSA-5220959] TDG excises 5-formylcytosine

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