Reactome | TDG excises 5-formylcytosine

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TDG excises 5-formylcytosine Show undefined attributes

authored	[InstanceEdit:5220992] May, B, 2013-12-28
catalystActivity	[CatalystActivity:110209] DNA N-glycosylase activity of TDG [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5221003] May, B, 2013-12-30
dbId	5220959
displayName	TDG excises 5-formylcytosine
edited	[InstanceEdit:5220992] May, B, 2013-12-28
eventOf	[Pathway:R-HSA-5221030] TET1,2,3 and TDG demethylate DNA - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:9907540] chromosomal 5-methylcytosine DNA demethylation, oxidation pathway
input	[OtherEntity:R-ALL-5221062] DNA containing 5-fC [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-65812] TDG [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5220924] Thymine DNA glycosylase can rapidly excise 5-formylcytosine and 5-carboxylcytosine: potential implications for active demethylation of CpG sites [LiteratureReference:5222403] Crystal structure of human thymine DNA glycosylase bound to DNA elucidates sequence-specific mismatch recognition [LiteratureReference:5221024] Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA [LiteratureReference:5221043] Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA
maxDepth	1
modified	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
name	TDG excises 5-formylcytosine
orthologousEvent	[Reaction:R-SPO-5220959] TDG excises 5-formylcytosine - Schizosaccharomyces pombe [Reaction:R-DME-5220959] TDG excises 5-formylcytosine - Drosophila melanogaster [Reaction:R-GGA-5220959] TDG excises 5-formylcytosine - Gallus gallus [Reaction:R-XTR-5220959] TDG excises 5-formylcytosine - Xenopus tropicalis [Reaction:R-DRE-5220959] TDG excises 5-formylcytosine - Danio rerio [Reaction:R-SSC-5220959] TDG excises 5-formylcytosine - Sus scrofa [Reaction:R-BTA-5220959] TDG excises 5-formylcytosine - Bos taurus [Reaction:R-CFA-5220959] TDG excises 5-formylcytosine - Canis familiaris [Reaction:R-RNO-5220959] TDG excises 5-formylcytosine - Rattus norvegicus [Reaction:R-MMU-5220959] TDG excises 5-formylcytosine - Mus musculus
output	[SimpleEntity:R-ALL-5221065] 5-fC [nucleoplasm] [Complex:R-HSA-110191] TDG:AP-dsDNA [nucleoplasm]
precedingEvent	[Reaction:R-HSA-5220990] TET1,2,3 oxidizes 5-hydroxymethylcytosine to 5-formylcytosine - Homo sapiens
releaseDate	2014-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5250662] Pfeifer, Gerd P, 2014-01-29 [InstanceEdit:5333791] Mukherji, Mridul, 2014-02-21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5220959
summation	[Summation:5222401] Thymine DNA glycosylase (TDG) excises 5-formylcytosine (5-fC...

Referrals

(hasEvent)

[Pathway:R-HSA-5221030] TET1,2,3 and TDG demethylate DNA