Reactome | Activation of recruited TAK1

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Activation of recruited TAK1 Show undefined attributes

authored	[InstanceEdit:434153] Shamovsky, V, 2009-08-26
catalystActivity	[CatalystActivity:434006] protein serine/threonine kinase activity of viral dsRNA : TLR3 : TICAM1 : pUb_TRAF6 :TAB2 :TAB3: TAK1 : TAB1: free_pUb_chain [endosome membrane]
category	transition
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:434122] Shamovsky, V, 2009-08-26
dbId	433957
displayName	Activation of recruited TAK1
edited	[InstanceEdit:2272816] Shamovsky, V, 2012-05-25
eventOf	[Pathway:R-GGA-433871] TRAF6 mediated induction of proinflammatory cytokines - Gallus gallus
followingEvent	[Reaction:R-GGA-921145] Activated chicken TAK1 dissociates from the activated TLR3 complex - Gallus gallus [Reaction:R-GGA-437984] Phosphorylation of MKK3/MKK6 by activated TAK1 - Gallus gallus [Reaction:R-GGA-437999] Phosphorylation of MKK4 by activated TAK1 - Gallus gallus [Reaction:R-GGA-433955] Phosphorylation of IKKs complex by activated TAK1 - Gallus gallus
inferredFrom	[Reaction:R-HSA-177692] Activation of recruited TAK1 within the activated TLR3 complex - Homo sapiens
input	4 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-GGA-434146] viral dsRNA : TLR3 : TICAM1 : pUb_TRAF6 :TAB2 :TAB3: TAK1 : TAB1: free_pUb_chain [endosome membrane]
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:571311] PKC beta regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1 [LiteratureReference:202523] Ubiquitin-mediated activation of TAK1 and IKK [LiteratureReference:208156] TAK1 is a ubiquitin-dependent kinase of MKK and IKK [LiteratureReference:433972] TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activation of recruited TAK1
output	4 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-GGA-434152] viral dsRNA : TLR3 : TICAM1 : pUb_TRAF6 :TAB2:TAB3 :phospho TAK1 : TAB1 : free pUb chain [endosome membrane]
precedingEvent	[Reaction:R-GGA-433950] TRAF6 recruits TAK1 kinase complex - Gallus gallus
relatedSpecies	[Species:9014381] Infectious bronchitis virus
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:789693] D'Eustachio, P, 2010-05-23
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-433957
summation	[Summation:434094] Polyubiquitinated TRAF6 activates TAK1 by binding to the ubi... [Summation:446239] Chicken TAK1 complex proteins TAK1, TAB1, TAB2 and TAB3, con...
updateTrackers	[UpdateTracker:9789969] Update Tracker - [Reaction:433957] Activation of recruited TAK1 - v36:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9789969] Update Tracker - [Reaction:433957] Activation of recruited TAK1 - v36:[modifyText]
(precedingEvent)	[Reaction:R-GGA-921145] Activated chicken TAK1 dissociates from the activated TLR3 complex [Reaction:R-GGA-437984] Phosphorylation of MKK3/MKK6 by activated TAK1 [Reaction:R-GGA-437999] Phosphorylation of MKK4 by activated TAK1 [Reaction:R-GGA-433955] Phosphorylation of IKKs complex by activated TAK1
(hasEvent)	[Pathway:R-GGA-433871] TRAF6 mediated induction of proinflammatory cytokines
(inferredTo)	[Reaction:R-HSA-177692] Activation of recruited TAK1 within the activated TLR3 complex

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