Reactome | Phosphorylation of IKKs complex by activated TAK1

Schema > Reaction > Entries

Phosphorylation of IKKs complex by activated TAK1 Show undefined attributes

authored	[InstanceEdit:434153] Shamovsky, V, 2009-08-26
catalystActivity	[CatalystActivity:434076] protein serine/threonine kinase activity of Activated chicken TAK1 complexes [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:434122] Shamovsky, V, 2009-08-26
dbId	433955
displayName	Phosphorylation of IKKs complex by activated TAK1
edited	[InstanceEdit:668815] Shamovsky, V, 2010-05-04
eventOf	[Pathway:R-GGA-434001] TAK1 activates NFkB by phosphorylation and activation of IKKs complex - Gallus gallus
followingEvent	[Reaction:R-GGA-433986] activated IKKs phosphorylates IkB alpha causing the NFkB complex to dissociate from the phospho-IkB - Gallus gallus
inferredFrom	[Reaction:R-HSA-168184] Activated TAK1 mediates phosphorylation of the IKK Complex - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-GGA-434005] IKKs_complex (Inhibitor of kappa B kinases) [cytosol]
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:434145] Multiple functions of the IKK-related kinase IKKepsilon in interferon-mediated antiviral immunity [LiteratureReference:202505] Regulation and function of IKK and IKK-related kinases [LiteratureReference:202523] Ubiquitin-mediated activation of TAK1 and IKK
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylation of IKKs complex by activated TAK1
orthologousEvent	[Reaction:R-HSA-1168641] TAK1 associated with the CBM complex phosphorylates IKKbeta - Homo sapiens
output	[Complex:R-GGA-433938] activated IKKs complex [cytosol] 2 × [SimpleEntity:R-ALL-29370] ADP [cytosol]
precedingEvent	[Reaction:R-GGA-433957] Activation of recruited TAK1 - Gallus gallus [Reaction:R-GGA-451447] Activation of recruited TAK1 within the complex p-IRAK2: pUb-TRAF6:TAB2/TAB3:TAB1:TAK1 - Gallus gallus
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:789693] D'Eustachio, P, 2010-05-23
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-433955
summation	[Summation:433894] The IKKs - IkB kinase (IKK) complex serves as the master re...

Referrals

(hasEvent)	[Pathway:R-GGA-434001] TAK1 activates NFkB by phosphorylation and activation of IKKs complex
(precedingEvent)	[Reaction:R-GGA-433986] activated IKKs phosphorylates IkB alpha causing the NFkB complex to dissociate from the phospho-IkB
(inferredTo)	[Reaction:R-HSA-168184] Activated TAK1 mediates phosphorylation of the IKK Complex

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