Reactome | ceramide + H2O => stearate + sphingosine [endoplasmic reticulum]

Schema > Reaction > Entries

catalystActivity	[CatalystActivity:433548] N-acylsphingosine amidohydrolase activity of ACER1 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:433625] D'Eustachio, P, 2009-08-22
dbId	433608
displayName	ceramide + H2O => stearate + sphingosine [endoplasmic reticulum]
eventOf	[Pathway:R-GGA-433584] Sphingolipid metabolism - Gallus gallus
inferredFrom	[Reaction:R-HSA-428231] ACER1 hydrolyzes ceramide (endoplasmic reticulum) - Homo sapiens
input	[SimpleEntity:R-ALL-428256] CERA [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	true
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ceramide + H2O => stearate + sphingosine [endoplasmic reticulum]
output	[SimpleEntity:R-ALL-428193] SPG [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-428198] STEA [early endosome]
precedingEvent	[Reaction:R-GGA-433599] dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O - Gallus gallus
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-433608
summation	[Summation:433571] ACER1 (alkaline ceramidase 1), associated with the endoplasm...

(hasEvent)	[Pathway:R-GGA-433584] Sphingolipid metabolism
(inferredTo)	[Reaction:R-HSA-428231] ACER1 hydrolyzes ceramide (endoplasmic reticulum)

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