Reactome | ALOX5 oxidises 15S-HpETE to LXA4/B4

Schema > Reaction > Entries

ALOX5 oxidises 15S-HpETE to LXA4/B4 Show undefined attributes

catalystActivity	[CatalystActivity:10779927] oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen of ALOX5:ALOX5AP:LTC4S [nuclear envelope]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10779931
displayName	ALOX5 oxidises 15S-HpETE to LXA4/B4
eventOf	[Pathway:R-GGA-2142700] Biosynthesis of Lipoxins (LX) - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-2161779] LXA4 is oxidised to 15k-LXA4 by HPGD - Gallus gallus
inferredFrom	[Reaction:R-HSA-2161917] ALOX5 oxidises 15S-HpETE to LXA4/B4 - Homo sapiens
input	2 × [SimpleEntity:R-ALL-2142718] 15S-HpETE [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	ALOX5 oxidises 15S-HpETE to LXA4/B4
output	2 × [DefinedSet:R-ALL-2161856] LXA4/B4 [cytosol]
precedingEvent	[Reaction:R-GGA-2162002] Arachidonate is oxidised to 15S-HpETE by ALOX15/15B - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-2161917
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-2142700] Biosynthesis of Lipoxins (LX)
(precedingEvent)	[Reaction:R-GGA-2161779] LXA4 is oxidised to 15k-LXA4 by HPGD
(inferredTo)	[Reaction:R-HSA-2161917] ALOX5 oxidises 15S-HpETE to LXA4/B4

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