Reactome | LXA4 is oxidised to 15k-LXA4 by HPGD

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LXA4 is oxidised to 15k-LXA4 by HPGD Show undefined attributes

catalystActivity	[CatalystActivity:10779889] 15-hydroxyprostaglandin dehydrogenase (NAD+) activity of HPGD dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10779891
displayName	LXA4 is oxidised to 15k-LXA4 by HPGD
eventOf	[Pathway:R-GGA-2142700] Biosynthesis of Lipoxins (LX) - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-2161779] LXA4 is oxidised to 15k-LXA4 by HPGD - Homo sapiens
input	[SimpleEntity:R-ALL-2161759] LXA4 [cytosol] [SimpleEntity:R-ALL-29360] NAD+ [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	LXA4 is oxidised to 15k-LXA4 by HPGD lipoxin A4 + NAD(+) => 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + H(+) + NADH
output	[SimpleEntity:R-ALL-2142761] 15k-LXA4 [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-73473] NADH [cytosol]
precedingEvent	[Reaction:R-GGA-2161917] ALOX5 oxidises 15S-HpETE to LXA4/B4 - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-2161779
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-2142700] Biosynthesis of Lipoxins (LX)
(inferredTo)	[Reaction:R-HSA-2161779] LXA4 is oxidised to 15k-LXA4 by HPGD

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