Reactome | C5b:C6:C7 inserts into the target cell membrane

Schema > Reaction > Entries

C5b:C6:C7 inserts into the target cell membrane Show undefined attributes

authored	[InstanceEdit:2869458] Shamovsky, V, 2012-12-20
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:2132098] Shamovsky, V, 2012-02-21
dbId	2132133
displayName	C5b:C6:C7 inserts into the target cell membrane
edited	[InstanceEdit:5149549] Shamovsky, V, 2013-11-19
eventOf	[Pathway:R-GGA-2132267] Formation of membrane attack complex (MAC) - Gallus gallus
followingEvent	[Reaction:R-GGA-2132094] C8 binds to C5b:C6:C7 complement complex - Gallus gallus
inferredFrom	[Reaction:R-HSA-173709] C7 binds C5b:C6 - Homo sapiens
input	[Complex:R-GGA-2132072] C5b:C6:C7 [extracellular region]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:2132291] Cloning of the sixth complement component and, spatial and temporal expression profile of MAC structural and regulatory genes in chicken
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	C5b:C6:C7 inserts into the target cell membrane
output	[Complex:R-GGA-2132054] C5b:C6:C7 [plasma membrane]
precedingEvent	[Reaction:R-GGA-2132060] Formation of C5b:C6:C7 - Gallus gallus
regulatedBy	[NegativeRegulation:R-GGA-2132132] Negative regulation by 'VTN:C5b:C6:C7 [extracellular region]'
releaseDate	2014-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2562608] D'Eustachio, P, 2012-11-06 [InstanceEdit:3006589] Jupe, S, 2013-01-31
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-2132133
summation	[Summation:2173558] Upon binding of C7 to C5b:C6, the trimolecular C5b:C6:C7 com...
updateTrackers	[UpdateTracker:9786136] Update Tracker - [Reaction:2132133] C5b:C6:C7 inserts into the target cell membrane - v50:[add_removeRegulator]

Referrals

(updatedInstance)	[UpdateTracker:9786136] Update Tracker - [Reaction:2132133] C5b:C6:C7 inserts into the target cell membrane - v50:[add_removeRegulator]
(hasEvent)	[Pathway:R-GGA-2132267] Formation of membrane attack complex (MAC)
(precedingEvent)	[Reaction:R-GGA-2132094] C8 binds to C5b:C6:C7 complement complex
(inferredTo)	[Reaction:R-HSA-173709] C7 binds C5b:C6

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