Reactome | Caspase activation via Death Receptors in the presence of ligand

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Caspase activation via Death Receptors in the presence of ligand Show undefined attributes

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10825355
displayName	Caspase activation via Death Receptors in the presence of ligand
eventOf	[Pathway:R-GGA-5357769] Caspase activation via extrinsic apoptotic signalling pathway - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:423068] positive regulation of endopeptidase activity
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-GGA-69416] Dimerization of procaspase-8 - Gallus gallus [Reaction:R-GGA-2562564] Caspase-8 processing within TLR4 complex - Gallus gallus [Pathway:R-GGA-3371378] Regulation by c-FLIP - Gallus gallus
inferredFrom	[Pathway:R-HSA-140534] Caspase activation via Death Receptors in the presence of ligand - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Caspase activation via Death Receptors in the presence of ligand Ligand-dependent caspase activation
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49591] Gallus gallus
stId	R-GGA-140534
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEncapsulatedEvent)	[Pathway:R-GGA-75157] FasL/ CD95L signaling [Pathway:R-GGA-75893] TNF signaling [Pathway:R-GGA-75158] TRAIL signaling
(inferredTo)	[Pathway:R-HSA-140534] Caspase activation via Death Receptors in the presence of ligand
(hasEvent)	[Pathway:R-GGA-5357769] Caspase activation via extrinsic apoptotic signalling pathway

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