Reactome | activated thrombin (factor IIa) + antithrombin III:heparan sulfate -> thrombin:antithrombin III:heparan sulfate

Schema > Reaction > Entries

activated thrombin (factor IIa) + antithrombin III:heparan sulfate -> thrombin:antithrombin III:heparan sulfate Show undefined attributes

category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10739995
displayName	activated thrombin (factor IIa) + antithrombin III:heparan sulfate -> thrombin:antithrombin III:heparan sulfate
eventOf	[Pathway:R-GGA-9769739] Regulation of clotting cascade - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-140870] thrombin:antithrombin III:heparan sulfate -> thrombin:cleaved antithrombin III:heparan sulfate - Gallus gallus
inferredFrom	[Reaction:R-HSA-140791] activated thrombin (factor IIa) + antithrombin III:heparan sulfate -> thrombin:antithrombin III:heparan sulfate - Homo sapiens
input	[Complex:R-GGA-156786] activated thrombin (factor IIa) [extracellular region] [Complex:R-GGA-9823297] SERPINC1:HSPGs [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	activated thrombin (factor IIa) + antithrombin III:heparan sulfate -> thrombin:antithrombin III:heparan sulfate activated thrombin (factor IIa) + SERPINC1:HS -> thrombin:SERPINC1:HS
output	[Complex:R-GGA-140812] thrombin:SERPINC1:HSPGs [plasma membrane]
precedingEvent	[Reaction:R-GGA-140664] prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) - Gallus gallus [Reaction:R-GGA-9823290] SERPINC1 binds heparan sulfate - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-140791
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-9769739] Regulation of clotting cascade
(precedingEvent)	[Reaction:R-GGA-140870] thrombin:antithrombin III:heparan sulfate -> thrombin:cleaved antithrombin III:heparan sulfate
(inferredTo)	[Reaction:R-HSA-140791] activated thrombin (factor IIa) + antithrombin III:heparan sulfate -> thrombin:antithrombin III:heparan sulfate

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