Reactome | thrombin:antithrombin III:heparan sulfate -> thrombin:cleaved antithrombin III:heparan sulfate

Schema > Reaction > Entries

thrombin:antithrombin III:heparan sulfate -> thrombin:cleaved antithrombin III:heparan sulfate Show undefined attributes

catalystActivity	[CatalystActivity:10740014] serine-type endopeptidase activity of thrombin:SERPINC1:HSPGs [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10740016
displayName	thrombin:antithrombin III:heparan sulfate -> thrombin:cleaved antithrombin III:heparan sulfate
eventOf	[Pathway:R-GGA-9769739] Regulation of clotting cascade - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-140872] thrombin:cleaved SERPINC1:HSPGs-> thrombin:cleaved SERPINC1 + HSPGs - Gallus gallus
inferredFrom	[Reaction:R-HSA-140870] thrombin:antithrombin III:heparan sulfate -> thrombin:cleaved antithrombin III:heparan sulfate - Homo sapiens
input	[Complex:R-GGA-140812] thrombin:SERPINC1:HSPGs [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	thrombin:antithrombin III:heparan sulfate -> thrombin:cleaved antithrombin III:heparan sulfate
output	[Complex:R-GGA-140871] thrombin:cleaved SERPINC1:HSPGs [plasma membrane]
precedingEvent	[Reaction:R-GGA-140791] activated thrombin (factor IIa) + antithrombin III:heparan sulfate -> thrombin:antithrombin III:heparan sulfate - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-140870
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-9769739] Regulation of clotting cascade
(precedingEvent)	[Reaction:R-GGA-140872] thrombin:cleaved SERPINC1:HSPGs-> thrombin:cleaved SERPINC1 + HSPGs
(inferredTo)	[Reaction:R-HSA-140870] thrombin:antithrombin III:heparan sulfate -> thrombin:cleaved antithrombin III:heparan sulfate

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