Reactome | prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst)

Schema > Reaction > Entries

prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) Show undefined attributes

catalystActivity	[CatalystActivity:10739712] serine-type endopeptidase activity of FVa:FXa [plasma membrane]
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10739716
displayName	prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst)
eventOf	[Pathway:R-GGA-9769743] Amplification and propagation of coagulation cascade - Gallus gallus [Pathway:R-GGA-9769735] Initiation of coagulation cascade - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-140791] activated thrombin (factor IIa) + antithrombin III:heparan sulfate -> thrombin:antithrombin III:heparan sulfate - Gallus gallus [Reaction:R-GGA-140599] factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides - Gallus gallus [Reaction:R-GGA-158419] factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) - Gallus gallus [Reaction:R-GGA-140696] factor V -> factor Va + factor V activation peptide (thrombin catalyst) - Gallus gallus
inferredFrom	[Reaction:R-HSA-140664] prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) - Homo sapiens
input	[EntityWithAccessionedSequence:R-GGA-140674] F2 [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) FII -> FIIa + FII activation peptide (FVa:FXa catalyst)
output	[Complex:R-GGA-156786] activated thrombin (factor IIa) [extracellular region] [EntityWithAccessionedSequence:R-GGA-140786] F2 [extracellular region]
precedingEvent	[Reaction:R-GGA-140686] factor Va + factor Xa -> Va:Xa complex (prothrombinase) - Gallus gallus
regulatedBy	[NegativeRegulation:10739717] Negative regulation by 'Va:Xa:Factor Xa inhibitors [plasma membrane]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-140664
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-GGA-140791] activated thrombin (factor IIa) + antithrombin III:heparan sulfate -> thrombin:antithrombin III:heparan sulfate [Reaction:R-GGA-140599] factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides [Reaction:R-GGA-158419] factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) [Reaction:R-GGA-140696] factor V -> factor Va + factor V activation peptide (thrombin catalyst)
(hasEvent)	[Pathway:R-GGA-9769743] Amplification and propagation of coagulation cascade [Pathway:R-GGA-9769735] Initiation of coagulation cascade
(inferredTo)	[Reaction:R-HSA-140664] prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst)