Reactome | Erythrocytes take up carbon dioxide and release oxygen

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Erythrocytes take up carbon dioxide and release oxygen Show undefined attributes

compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10827177
displayName	Erythrocytes take up carbon dioxide and release oxygen
eventOf	[Pathway:R-GGA-1480926] O2/CO2 exchange in erythrocytes - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:24814] bicarbonate transport
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-GGA-1237047] CA4:Zn2+ hydrates CO2 to HCO3- - Gallus gallus [Reaction:R-GGA-1237042] AQP1 tetramer transports CO2 from extracellular region to cytosol - Gallus gallus [Reaction:R-GGA-1237069] RHAG transports CO2 from extracellular region to cytosol - Gallus gallus [Reaction:R-GGA-1475435] CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- - Gallus gallus [Reaction:R-GGA-9707419] CA1:Zn2+,CA2:Zn2+ bind CA inhibitors - Gallus gallus [Reaction:R-GGA-1237038] SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- - Gallus gallus [Reaction:R-GGA-1237325] Hemoglobin A is protonated and carbamated causing release of oxygen - Gallus gallus [Reaction:R-GGA-6806831] CYB5Rs reduce MetHb to HbA - Gallus gallus
inferredFrom	[Pathway:R-HSA-1237044] Erythrocytes take up carbon dioxide and release oxygen - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Erythrocytes take up carbon dioxide and release oxygen
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49591] Gallus gallus
stId	R-GGA-1237044
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-1480926] O2/CO2 exchange in erythrocytes
(inferredTo)	[Pathway:R-HSA-1237044] Erythrocytes take up carbon dioxide and release oxygen