Reactome | TF:FVIIa:FXa ->TF:FVIIa + FXa

Schema > Reaction > Entries

TF:FVIIa:FXa ->TF:FVIIa + FXa Show undefined attributes

category	dissociation
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10642871
displayName	TF:FVIIa:FXa ->TF:FVIIa + FXa
eventOf	[Pathway:R-DRE-9769735] Initiation of coagulation cascade - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-9769737] factor V -> factor Va intermediate + factor V activation peptide (FXa catalyst) - Danio rerio [Reaction:R-DRE-140700] prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) - Danio rerio [Reaction:R-DRE-140769] factor VII -> factor VIIa - Danio rerio [Reaction:R-DRE-9933742] factor Va intermediate + factor Xa -> factor Va intermediate:factor Xa - Danio rerio [Reaction:R-DRE-140686] factor Va + factor Xa -> Va:Xa complex (prothrombinase) - Danio rerio [Reaction:R-DRE-9929051] TF:FVIIa+FIX -> TF:FVIIa:FIXa + FIX activation peptide (TF:F7a catalyst) - Danio rerio [Reaction:R-DRE-9822514] TF:FVIIa+FX -> TF:FVIIa:FXa + FX activation peptide (TF:F7a catalyst) - Danio rerio [Reaction:R-DRE-9930792] factor Va intermediate -> factor Va - Danio rerio
inferredFrom	[Reaction:R-HSA-9822512] TF:FVIIa:FXa ->TF:FVIIa + FXa - Homo sapiens
input	[Complex:R-DRE-9822516] TF:FVIIa:FXa [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	TF:FVIIa:FXa ->TF:FVIIa + FXa FXa dissociates from TF:FVIIa:FXa
output	[Complex:R-DRE-140689] factor Xa [extracellular region] [Complex:R-DRE-140734] TF:FVIIa [plasma membrane]
precedingEvent	[Reaction:R-DRE-9929060] TF:FVII:FXa ->TF:FVIIa:FXa (FXa catalyst) - Danio rerio [Reaction:R-DRE-9822514] TF:FVIIa+FX -> TF:FVIIa:FXa + FX activation peptide (TF:F7a catalyst) - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-9822512
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-9769735] Initiation of coagulation cascade
(precedingEvent)	[Reaction:R-DRE-9933742] factor Va intermediate + factor Xa -> factor Va intermediate:factor Xa [Reaction:R-DRE-140686] factor Va + factor Xa -> Va:Xa complex (prothrombinase) [Reaction:R-DRE-9930792] factor Va intermediate -> factor Va [Reaction:R-DRE-9769737] factor V -> factor Va intermediate + factor V activation peptide (FXa catalyst) [Reaction:R-DRE-140700] prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) [Reaction:R-DRE-9929051] TF:FVIIa+FIX -> TF:FVIIa:FIXa + FIX activation peptide (TF:F7a catalyst) [Reaction:R-DRE-140769] factor VII -> factor VIIa [Reaction:R-DRE-9822514] TF:FVIIa+FX -> TF:FVIIa:FXa + FX activation peptide (TF:F7a catalyst)
(inferredTo)	[Reaction:R-HSA-9822512] TF:FVIIa:FXa ->TF:FVIIa + FXa

Cite Us!