Reactome | prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst)

Schema > Reaction > Entries

prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) Show undefined attributes

catalystActivity	[CatalystActivity:10568000] serine-type endopeptidase activity of factor Xa [extracellular region]
category	transition
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10568004
displayName	prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst)
eventOf	[Pathway:R-DRE-9769735] Initiation of coagulation cascade - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-140696] factor V -> factor Va + factor V activation peptide (thrombin catalyst) - Danio rerio
inferredFrom	[Reaction:R-HSA-140700] prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) - Homo sapiens
input	[EntityWithAccessionedSequence:R-DRE-140674] f2 [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst)
output	[Complex:R-DRE-156786] activated thrombin (factor IIa) [extracellular region] [EntityWithAccessionedSequence:R-DRE-140786] f2 [extracellular region]
precedingEvent	[Reaction:R-DRE-9822512] TF:FVIIa:FXa ->TF:FVIIa + FXa - Danio rerio
regulatedBy	[NegativeRegulation:10568005] Negative regulation by 'factor Xa:Factor Xa inhibitors [plasma membrane]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-140700
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-9769735] Initiation of coagulation cascade
(precedingEvent)	[Reaction:R-DRE-140696] factor V -> factor Va + factor V activation peptide (thrombin catalyst)
(inferredTo)	[Reaction:R-HSA-140700] prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst)

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