Reactome | MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs

Schema > Reaction > Entries

MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs Show undefined attributes

catalystActivity	[CatalystActivity:10639999] protein serine/threonine phosphatase activity of S-GCC MRAS:GTP:SHOC2:PP1 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10640001
displayName	MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs
eventOf	[Pathway:R-DRE-5673000] RAF activation - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9658445] MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [Complex:R-DRE-5672707] inactive RAFs:YWHAB dimer [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs
output	[Complex:R-DRE-5672728] dephosphorylated inactive RAFS:YWHAB dimer [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-DRE-5672951] Inactive RAFs bind YWHAB - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-9658445
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-5673000] RAF activation
(inferredTo)	[Reaction:R-HSA-9658445] MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs

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